CAJ | 학술논문

创新实验大学生利用数理统计学的相关知识，按照《中国药典》2010年版附录Ⅻ中的要求，测定胰岛素类似物的生物活性。通过交叉设计的方差分析及假设检验，评判胰岛素标准品与胰岛素类似物供试品引起小鼠血糖下降的作用，对实验中同批小鼠的给药时间间隔、胰岛素类似物母液储备时间进行探索，并计算胰岛素类似物的效价。创新实验大学生通过此次胰岛素类似物生物活性测定实验增强实验技能，合理利用数理统计解决了实际问题，并培养了严谨求实的科学态度。
창신실험대학생이용수리통계학적상관지식，안조《중국약전》2010년판부록Ⅻ중적요구，측정이도소유사물적생물활성。통과교차설계적방차분석급가설검험，평판이도소표준품여이도소유사물공시품인기소서혈당하강적작용，대실험중동비소서적급약시간간격、이도소유사물모액저비시간진행탐색，병계산이도소유사물적효개。창신실험대학생통과차차이도소유사물생물활성측정실험증강실험기능，합리이용수리통계해결료실제문제，병배양료엄근구실적과학태도。
By using mathematical statistics and referring to the Appendix Ⅻ of China Pharmacopoeia 2010,the bioactivity of insulin analogue was determined by undergraduates in innovative experiment.The hypoglycemic effects in the mouse of the insulin analogue and the insulin were evaluated by hypothesis tes-ting and crossover design analysis of variance,exploring the dosing intervals for the same batch of mice and storage time of insulin analogue’s mother liquor,and calculating the insulin analogue potency.Through the experiment for determination of insulin analogue’s bioactivity,students strengthened the experimental skills,solved problems by using mathematical statistics,and cultivated their rigorous scientific attitude.