CAJ | 학술논문

目的：观察鼻内激素联合孟鲁司特治疗儿童阻塞性睡眠呼吸暂停低通气综合征（ obstructive sleep ap-nea-hypopnea syndrom，OSAHS）的短期疗效。方法入选的51例OSAHS患儿作为研究对象，随机分成2组。联合用药组（n＝26）采用鼻内激素与孟鲁司特联合治疗，对照组（n＝25）单用鼻内激素治疗。均连续治疗12周。治疗前后进行电子鼻咽镜检查，统计患者治疗前后睡眠呼吸暂停低通气指数（ AHI）和最低血氧饱和度（ Lsao2），比较2组的差异。结果治疗前与治疗后电子鼻咽镜检查腺样体缩小程度组间比较差异无统计学意义（P＞0．05），而治疗后2组睡眠呼吸监测的主要指标AHI及Lsao2的差异有统计学意义（P＜0．05）。结论鼻内激素联合孟鲁司特治疗儿童OSAHS的短期疗效优于单纯使用鼻内激素。
목적：관찰비내격소연합맹로사특치료인동조새성수면호흡잠정저통기종합정（ obstructive sleep ap-nea-hypopnea syndrom，OSAHS）적단기료효。방법입선적51례OSAHS환인작위연구대상，수궤분성2조。연합용약조（n＝26）채용비내격소여맹로사특연합치료，대조조（n＝25）단용비내격소치료。균련속치료12주。치료전후진행전자비인경검사，통계환자치료전후수면호흡잠정저통기지수（ AHI）화최저혈양포화도（ Lsao2），비교2조적차이。결과치료전여치료후전자비인경검사선양체축소정도조간비교차이무통계학의의（P＞0．05），이치료후2조수면호흡감측적주요지표AHI급Lsao2적차이유통계학의의（P＜0．05）。결론비내격소연합맹로사특치료인동OSAHS적단기료효우우단순사용비내격소。
Objective To observe the short-term efficacy of combined treatment with intranasal steroids and mon-telukast for Obstructive Sleep Apnea Hypopnea Syndrome in children.Methods 51 cases of children with OSAHS were selected, and randomly divide drug combination group ( n=26 ) treated with intranasal steroids combined with monte-lukast for 12 weeks and control group ( n=25) treated with intranasal steroids only for 12 weeks.Electronic nasopharyn-goscope examination were performed before and after treatment and compare the difference between two groups,and com-pare the difference between the main indicators of sleep respiratory monitoring in the two groups: sleep apnea hypopnea index ( AHI) and the lowest oxygen saturation ( Lsao2 ) .Results There is no statistically significant difference between the two groups after the treatment of electronic nasopharyngoscopy adenoids shrink degree (P>0.05), while a statistical-ly significant difference exists between the two groups:AHI and Lsao2 after the treatment of sleep respiration monitoring index (P<0.05).Conclusion The short-term effect of combined treatment with intranasal corticosteroids and monte-lukast is better than that of treatment with intranasal steroids only in the children with OSAHS.