CAJ | 학술논문

目的：研究丹皮酚结肠靶向片剂在大鼠体内定位释药性能。方法：特制适合大鼠口服给药的3mm结肠定位包衣小片,通过相似性因子?2评价包衣小片和包衣大片释放曲线的相似性,以小片代替大片进行体内释放评价,考察结肠靶向包衣片剂在大鼠胃、肠道中的释放性能。结果：特制包衣小片的隔离层、时滞层、肠溶层分别增重1.6%、7.3%、9.7%时,释放曲线与包衣大片大致相同,?2为53,丹皮酚结肠靶向片75%的药物释放在小肠后端、盲肠以及结肠段,胃及小肠前、中段仅有少量释放。结论：丹皮酚结肠靶向片剂基本达到了结肠定位释药的效果。
목적：연구단피분결장파향편제재대서체내정위석약성능。방법：특제괄합대서구복급약적3mm결장정위포의소편,통과상사성인자?2평개포의소편화포의대편석방곡선적상사성,이소편대체대편진행체내석방평개,고찰결장파향포의편제재대서위、장도중적석방성능。결과：특제포의소편적격리층、시체층、장용층분별증중1.6%、7.3%、9.7%시,석방곡선여포의대편대치상동,?2위53,단피분결장파향편75%적약물석방재소장후단、맹장이급결장단,위급소장전、중단부유소량석방。결론：단피분결장파향편제기본체도료결장정위석약적효과。
Objective:To investigate evaluate the absorption property of paeonol colon-specific tablets in vivo.Methods:Using the prescription and technology of big tablet to prepare 3 mm Colon-specific tablet and using it for the experiment in vivo evaluation.In completely perfused rat gastric model was used to investi-gate the releasing property of paeonol colon-specific tablets in vivo.Results:1 .6% weight increase of the iso-lated layer,7.3% weight increase of the sustained-release layer and 9.7% weight increase of the enteric lay-er,the release curve of the special coating tablets was similar to the big tablets and the?2 was 53.75% of the quantities distributed in enteric backend,cecal,colonic tissue and detected a little in gastric and middle of en-teric tissue,but not detected in front of enteric tissue.Conclusion:Paeonol colon-specific tablets have rough-ly reached the effect of the colon-specific drug release.