CAJ | 학술논문

目的：观察肠炎平正I号方加味灌肠治疗放射性肠炎的临床疗效。方法将90例放射性肠炎患者随机分为治疗组与对照组，各45例。两组均进行基础治疗，治疗组采用肠炎平正I号方加味灌肠治疗，对照组采用常规西药灌肠治疗。观察比较两组的临床疗效及腹泻、腹痛等症状积分、KPS积分，并检测治疗前后CD3+、CD4+、CD8+等免疫指标水平的变化。结果治疗组总有效率为93.3%，高于对照组的75.6%（P＜0.05）；除对照组乏力症状外，两组其他症状积分治疗前后组内比较及治疗后组间比较，差异均有统计学意义（P＜0.01，P＜0.05）；治疗组CD4+、CD8+、CD4+/CD8+治疗前后组内比较，差异均有统计学意义（P＜0.05）；治疗后两组CD3+、CD4+、CD8+组间比较，差异无统计学意义（P＞0.05），但两组CD4+/CD8+组间比较，差异有统计学意义（P＜0.05）。KPS积分治疗组治疗前后组内比较，差异有统计学意义（P＜0.05）；治疗后组间比较，差异有统计学意义（P＜0.05）。结论肠炎平正I号方加味灌肠治疗放射性肠炎疗效显著。
목적：관찰장염평정I호방가미관장치료방사성장염적림상료효。방법장90례방사성장염환자수궤분위치료조여대조조，각45례。량조균진행기출치료，치료조채용장염평정I호방가미관장치료，대조조채용상규서약관장치료。관찰비교량조적림상료효급복사、복통등증상적분、KPS적분，병검측치료전후CD3+、CD4+、CD8+등면역지표수평적변화。결과치료조총유효솔위93.3%，고우대조조적75.6%（P＜0.05）；제대조조핍력증상외，량조기타증상적분치료전후조내비교급치료후조간비교，차이균유통계학의의（P＜0.01，P＜0.05）；치료조CD4+、CD8+、CD4+/CD8+치료전후조내비교，차이균유통계학의의（P＜0.05）；치료후량조CD3+、CD4+、CD8+조간비교，차이무통계학의의（P＞0.05），단량조CD4+/CD8+조간비교，차이유통계학의의（P＜0.05）。KPS적분치료조치료전후조내비교，차이유통계학의의（P＜0.05）；치료후조간비교，차이유통계학의의（P＜0.05）。결론장염평정I호방가미관장치료방사성장염료효현저。
〔Abstract〕 Objective To observe the clinical efficacy of modified Changyanping No. I enema in the treatment of radiation enteritis.Methods Ninety patients with radiation enteritis were randomly divided into the treatment group and control group, 45 cases in each group. In addition to basic treatment, modified Changyanping No. I enema was given to the treatment group, while a conventional Western medicine enema to the control group. The two groups were compared in terms of clinical outcome, scores of diarrhea, abdominal pain, and other symptoms, and Karnofsky Performance Scale (KPS) score, and the changes of immune indices such as CD3+, CD4+, and CD8+ T cells were detected. Results The total effective rate of treatment group was 93.33%, which was higher than 75.6% of the control group (P<0.05). Except for the fatigue symptom in the control group, the two groups showed significant changes in other symptom scores, which also varied significantly between the two groups (P<0.01, P<0.05). After treatment, the treatment group showed significant changes in CD4+ and CD8+ T cells and CD4+/CD8+ ratio (P<0.05), there were no significant differences in CD3+, CD4+, and CD8+ T cells between the two groups (P>0.05), but a significant difference in CD4+/CD8+ ratio was observed between the two groups (P<0.05). After treatment, the treatment group showed a significant change in KPS score (P<0.05), there was a significant difference in KPS score between the two groups (P<0.05). Conclusion Modified Changyanping No. I enema shows significant efficacy in treatment of radiation enteritis.