CAJ | 학술논문

目的：探析多排CT灌注成像在脑梗塞前期患者脑血流动力学改变及分期中的应用。方法选择2013年4月-2015年4月来我院就诊的57例门诊/住院患者作为研究对象，所有患者均行常规CT平扫、增强扫描及动态CT扫描。获取rCBV、rCBF、MTT、TTP等脑血流动力学参数脑并将病侧与健侧各参数值进行比较以凸显脑梗塞前期患者脑血流动力学变化情况。结果患者病侧与健侧的CBV值接近，比较无统计学意义(P＞0.05)，但病侧CBF明显低于健侧、MTT与TTP则高于健侧，提示脑梗死的发生导致CBF减低、MTT与TTP延长，差异的比较有统计学意义(P＜0.05)。结论多排CT灌注成像可明确提示脑梗塞前期血流动力学异常，并通过脑血流动力学参数变化幅度对脑梗塞前期进行分期，掌握脑局部低灌注的病理生理学状态，对于疾病防治具有显著临床价值。
목적：탐석다배CT관주성상재뇌경새전기환자뇌혈류동역학개변급분기중적응용。방법선택2013년4월-2015년4월래아원취진적57례문진/주원환자작위연구대상，소유환자균행상규CT평소、증강소묘급동태CT소묘。획취rCBV、rCBF、MTT、TTP등뇌혈류동역학삼수뇌병장병측여건측각삼수치진행비교이철현뇌경새전기환자뇌혈류동역학변화정황。결과환자병측여건측적CBV치접근，비교무통계학의의(P＞0.05)，단병측CBF명현저우건측、MTT여TTP칙고우건측，제시뇌경사적발생도치CBF감저、MTT여TTP연장，차이적비교유통계학의의(P＜0.05)。결론다배CT관주성상가명학제시뇌경새전기혈류동역학이상，병통과뇌혈류동역학삼수변화폭도대뇌경새전기진행분기，장악뇌국부저관주적병리생이학상태，대우질병방치구유현저림상개치。
Objective To explore the application of CT perfusion imaging in changes and staging of cerebral hemodynamics in patients with pre-cerebral infarction.Methods 57 outpatients and inpatients admitted into the hospital for treatemtn during April 2013 to April 2015 were treated as the research objects. All patients underwent conventional CT plain scan, enhanced scan and dynamic CT scan. rCBV, rCBF, MTT, TTP and other cerebral hemodynamic parameters were obtained and the parameters of the diseased side and healthy side were compared to highlight the changes of cerebral hemodynamics in patients with pre-cerebral infarction.Results The CBV values of the diseased side and healthy side of patients were close and the comparison was not statistically significant (P>0.05), but CBF of the diseased side was significantly lower than that of the healthy side while MTT and TTP were higher than those of the healthy side. It suggested that the occurrence of cerebral infarction resulted in decreasing CBF and prolonged MTT and TTP. The differences were statistically significant (P<0.05).Conclusion Multi-slice CT perfusion imaging can clearly prompted hemodynamic abnormalities of pre-cerebral infarction. And through the change amplitude of cerebral hemodynamic parameters, pre-cerebral infarction is staged to master the pathophysiological state of regional cerebral low perfusion, which is of significant clinical value in preventing and treating the disease.