CAJ | 학술논문

为研究治疗剂量的多西环素在肉鸡可食性组织中的残留消除特点,多西环素以100 mg/L水(Ⅰ组)和100 mg/kg饲料(Ⅱ组) ,分别通过饮水和拌料2个途径给药,在不同的时间收集组织样品,采用高效液相色谱法,检测多西环素在肉鸡肝脏、肾脏、肌肉和皮肤+脂肪中的残留.结果显示,在给药期间,肉鸡组织中多西环素的浓度,随着时间的推移,在逐渐累积,于给药后第4天或第5天达到峰值.第Ⅰ组与第Ⅱ组比较,前者组织中浓度大多显著(P<0.05)或极显著(P<0.01)高于后者.而在停药后的第1天,肉鸡各组织中多西环素的浓度迅速下降,随后缓慢消除.停药后第14天时,2组鸡的肝脏、肾脏、肌肉、皮肤+脂肪中多西环素浓度均低于农业部规定的最高残留限量(MRLs).为安全考虑,多西环素以100 mg/L饮水给药和100 mg/kg拌料给药时,建议休药期为28 d.
위연구치료제량적다서배소재육계가식성조직중적잔류소제특점,다서배소이100 mg/L수(Ⅰ조)화100 mg/kg사료(Ⅱ조) ,분별통과음수화반료2개도경급약,재불동적시간수집조직양품,채용고효액상색보법,검측다서배소재육계간장、신장、기육화피부+지방중적잔류.결과현시,재급약기간,육계조직중다서배소적농도,수착시간적추이,재축점루적,우급약후제4천혹제5천체도봉치.제Ⅰ조여제Ⅱ조비교,전자조직중농도대다현저(P<0.05)혹겁현저(P<0.01)고우후자.이재정약후적제1천,육계각조직중다서배소적농도신속하강,수후완만소제.정약후제14천시,2조계적간장、신장、기육、피부+지방중다서배소농도균저우농업부규정적최고잔류한량(MRLs).위안전고필,다서배소이100 mg/L음수급약화100 mg/kg반료급약시,건의휴약기위28 d.
To study the residues of the therapeutic dose of doxycycline in broiler edible tissues,doxycyc-line was given at the concentrations of 100 mg/L(group 1) and 100 mg/kg(group 2) ,which was mixed in the drinking water and feed,samples of chicken' s live,kidney,muscle,skin-fat were taken at different times to measure their residue levels by means of the high performance liquid chromatography.The result showed as fol-lows,during administration,the concentration of doxycycline in the broiler tissue was gradually accumulated as time on,and reached the peak at the 4th or 5th days after the administration.Compared group 1 with group 2,the former' s concentration of the medicine was significantly (P<0.05) or very significantly higher (P<0.01) than that of the latter.In the days after the first withdrawal,the doxycycline concentration of the medicine in each tissue declined rapidly,and then eliminated slowly.In the days after the 14th withdrawal,the doxycycline con-centration in liver,kidney,muscle,skin and fat in group 1 and group 2 were below the maximum residue limitsprescribed by the Ministry of Agriculture.For the safe reason,when the doxycycline was given at 100 mg/L through the drinking water and 100 mg/kg through the feed,the withdrawal period should be 28 days.