海南医学
海南醫學
해남의학
Hainan Medical Journal
2015年
21期
3143-3145
,共3页
方力华%姚键%李伟仕%黄志勇%吴修信%陈旭明%林惠昌
方力華%姚鍵%李偉仕%黃誌勇%吳脩信%陳旭明%林惠昌
방력화%요건%리위사%황지용%오수신%진욱명%림혜창
抑郁%脑梗死%血清高敏C反应蛋白%肿瘤坏死因子-α
抑鬱%腦梗死%血清高敏C反應蛋白%腫瘤壞死因子-α
억욱%뇌경사%혈청고민C반응단백%종류배사인자-α
Depression%Cerebral infarction%High sensitivity C-reactive protein (hs-CRP)%Tumor necrosis factor-α(TNF-α)
目的 探讨抑郁情绪对脑梗死患者血清高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)的影响.方法 选取根据抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)评分判断为抑郁情绪的脑梗死患者45例作为抑郁组,选取无抑郁情绪的脑梗死患者45例作为非抑郁组,比较两组患者的血清hs-CRP及TNF-α水平.另外将上述90例脑梗死患者根据颅脑CT检查结果分为轻度(n=52)、中度(n=22)和重度(n=16)梗死组,比较三组患者的血清hs-CRP及TNF-α水平.结果 抑郁组患者的血清hs-CRP、TNF-α均显著高于非抑郁组,差异均具有显著统计学意义(P<0.01);轻度梗死组患者hs-CRP及TNF-α均显著低于中度梗死组,中度梗死组均显著低于重度梗死组,差异均具有显著统计学意义(P<0.01).结论 抑郁情绪将加重脑梗死患者的炎症反应,促使血清hs-CRP、TNF-α的增高,进而加重病情,因此脑梗死患者应给予积极心理干预,减轻其不良情绪,提高治疗效果,改善预后.
目的 探討抑鬱情緒對腦梗死患者血清高敏C反應蛋白(hs-CRP)、腫瘤壞死因子-α(TNF-α)的影響.方法 選取根據抑鬱自評量錶(SDS)、漢密爾頓抑鬱量錶(HAMD)評分判斷為抑鬱情緒的腦梗死患者45例作為抑鬱組,選取無抑鬱情緒的腦梗死患者45例作為非抑鬱組,比較兩組患者的血清hs-CRP及TNF-α水平.另外將上述90例腦梗死患者根據顱腦CT檢查結果分為輕度(n=52)、中度(n=22)和重度(n=16)梗死組,比較三組患者的血清hs-CRP及TNF-α水平.結果 抑鬱組患者的血清hs-CRP、TNF-α均顯著高于非抑鬱組,差異均具有顯著統計學意義(P<0.01);輕度梗死組患者hs-CRP及TNF-α均顯著低于中度梗死組,中度梗死組均顯著低于重度梗死組,差異均具有顯著統計學意義(P<0.01).結論 抑鬱情緒將加重腦梗死患者的炎癥反應,促使血清hs-CRP、TNF-α的增高,進而加重病情,因此腦梗死患者應給予積極心理榦預,減輕其不良情緒,提高治療效果,改善預後.
목적 탐토억욱정서대뇌경사환자혈청고민C반응단백(hs-CRP)、종류배사인자-α(TNF-α)적영향.방법 선취근거억욱자평량표(SDS)、한밀이돈억욱량표(HAMD)평분판단위억욱정서적뇌경사환자45례작위억욱조,선취무억욱정서적뇌경사환자45례작위비억욱조,비교량조환자적혈청hs-CRP급TNF-α수평.령외장상술90례뇌경사환자근거로뇌CT검사결과분위경도(n=52)、중도(n=22)화중도(n=16)경사조,비교삼조환자적혈청hs-CRP급TNF-α수평.결과 억욱조환자적혈청hs-CRP、TNF-α균현저고우비억욱조,차이균구유현저통계학의의(P<0.01);경도경사조환자hs-CRP급TNF-α균현저저우중도경사조,중도경사조균현저저우중도경사조,차이균구유현저통계학의의(P<0.01).결론 억욱정서장가중뇌경사환자적염증반응,촉사혈청hs-CRP、TNF-α적증고,진이가중병정,인차뇌경사환자응급여적겁심리간예,감경기불량정서,제고치료효과,개선예후.
Objective To discuss the clinical influence of depression on serum high sensitivity C-reactive pro-tein (hs-CRP) and tumor necrosis factor-α(TNF-α) in patients with cerebral infarction. Methods Forty-five patients diagnosed as cerebral infarction with depressed mood according to Self-Rating Depression Scale (SDS) and Hamilton Depression Rating Scale (HAMD) were selected as the depression group, and 45 patients without depressed mood were divided into the non-depression group. The serum hs-CRP and TNF-αwere compared between the two groups. The 90 patients were enrolled as the mild (n=52), moderate (n=22), and severe (n=16) infarction group according to the brain CT, and then the serum hs-CRP and TNF-αwere compared between the three groups. Results The serum hs-CRP and TNF-αlevels in the depression group were significantly higher than those in the non-depression group (P<0.01). Theserum hs-CRP and TNF-αlevels in the mild infarction group were significantly lower than those in the moderate in-farction group (P<0.01), and the levels in the moderate infarction group were significantly lower than those in the se-vere infarction group (P<0.01). Conclusion Depression can aggravate the inflammatory reaction in patients with ce-rebral infarction, and promote the increase of serum hs-CRP, TNF-α, thereby aggravate illness. Patients with cerebral infarction should be given active intervention to reduce the negative emotions, improve the therapeutic effects and prognosis.
