CAJ | 학술논문

目的探讨结肠癌组织中Cofilin-1蛋白的表达及其与肿瘤侵袭和转移的关系.方法应用免疫组织化学SP法检测60例结肠癌组织、40例癌旁正常组织、26例转移淋巴结组织标本中Cofilin-1蛋白的表达水平,并结合临床病理参数进行分析.结果 Cofilin-1蛋白在结肠癌组织、转移淋巴结组织中表达率分别为76.7%、61.5%,均明显高于癌旁正常组织中的32.5%表达率.Cofilin-1在结肠癌组织、转移淋巴结组织中的表达率明显高于癌旁正常组织,差异均有统计学意义(P<0.05);Cofilin-1蛋白的表达水平与结肠癌组织分化程度、Dukes分期、浆膜侵犯及淋巴结转移有关(P<0.05),而与性别、年龄、肿瘤大小无明显相关(P>0.05);Cofilin-1与结肠癌预后密切相关(P<0.05).结论检测Cofilin-1蛋白的表达有助于判断结肠癌的浸润、转移及预后.
목적 탐토결장암조직중Cofilin-1단백적표체급기여종류침습화전이적관계.방법 응용면역조직화학SP법검측60례결장암조직、40례암방정상조직、26례전이림파결조직표본중Cofilin-1단백적표체수평,병결합림상병리삼수진행분석.결과 Cofilin-1단백재결장암조직、전이림파결조직중표체솔분별위76.7%、61.5%,균명현고우암방정상조직중적32.5%표체솔.Cofilin-1재결장암조직、전이림파결조직중적표체솔명현고우암방정상조직,차이균유통계학의의(P<0.05);Cofilin-1단백적표체수평여결장암조직분화정도、Dukes분기、장막침범급림파결전이유관(P<0.05),이여성별、년령、종류대소무명현상관(P>0.05);Cofilin-1여결장암예후밀절상관(P<0.05).결론 검측Cofilin-1단백적표체유조우판단결장암적침윤、전이급예후.
Objective To investigate the expression of Cofilin-1 protein and its clinicopathological signifi-cance in colonic cancer. Methods The expression of Cofilin-1 protein in 60 colonic cancer specimens, 40 adjacent normal tissues, 26 lymph node metastasis tissues was detected by SP method. Meanwhile, the relationship between the expression of Cofilin-1 and the clinical pathologic factors was analyzed. Results The positive rate of Cofilin-1 expres-sion was 76.7%in colonic cancer specimens, 61.5%in lymph node metastasis tissues, which were significantly higher than 32.5% in adjacent normal tissues (P<0.05). Positive expression of Cofilin-1 protein was significantly associated with histology grading, Dukes stage, serosal invasion and lymph node metastasis (P<0.05), but not with gender, age and the size of tutor (P>0.05). Cofilin-1 was closely related to the prognosis of colonic cancer (P<0.05). Conclusion The detection of Cofilin-1 protein can help judge the invasion, metastasis and prognosis of colonic cancer.