检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
22期
3366-3367,3370
,共3页
妊娠糖尿病%糖化血红蛋白%糖化血清蛋白
妊娠糖尿病%糖化血紅蛋白%糖化血清蛋白
임신당뇨병%당화혈홍단백%당화혈청단백
gestational diabetes mellitus%glycosylated hemoglobin%glycosylated serum protein
目的：通过对妊娠糖尿病（GDM ）患者的糖化血红蛋白（HbA1c）和糖化血清蛋白（GSP）水平变化的检测，探讨两者联合检测在GDM 诊断中的重要意义。方法选取住院孕妇，162例诊断为妊娠期糖尿病（GDM组），94例糖耐量异常（IGT组），采用免疫比浊法检测HbA1c ，采用果糖胺氮蓝四唑法检测GSP ，采用氧化酶法检测血糖；同时与156例正常孕妇（正常对照组）检测指标比较。结果 IGT 组、GDM 组与正常对照组比较，GDM 组与IGT组比较，血糖、HbA1c和GSP水平均有统计学意义（P＜0．05）；IGT、GDM组与正常对照组比较，IGT、GDM 组内相互比较，HbA1c和GSP异常率差异均有统计学意义（P＜0．05）；在特异度、灵敏度、阳性预测值和正确诊断指数4项指标比较中，GSP均优于HbA1c ，分别为96．31％、89．78％、97．89％、91．94％；两者联合检测各指标值分别为98．63％、90．27％、98．65％、93．00％，说明两者联合检测用于诊断GDM 更为准确；相关性分析表明，正常对照组、IGT、GDM组的 HbA1c和GSP水平呈正相关（r分别为0．536、0．506、0．665，P＜0．05）。结论 HbA1c和GSP水平可以作为诊断GDM的重要指标，联合检测两者对GDM的诊断具有重要意义。
目的：通過對妊娠糖尿病（GDM ）患者的糖化血紅蛋白（HbA1c）和糖化血清蛋白（GSP）水平變化的檢測，探討兩者聯閤檢測在GDM 診斷中的重要意義。方法選取住院孕婦，162例診斷為妊娠期糖尿病（GDM組），94例糖耐量異常（IGT組），採用免疫比濁法檢測HbA1c ，採用果糖胺氮藍四唑法檢測GSP ，採用氧化酶法檢測血糖；同時與156例正常孕婦（正常對照組）檢測指標比較。結果 IGT 組、GDM 組與正常對照組比較，GDM 組與IGT組比較，血糖、HbA1c和GSP水平均有統計學意義（P＜0．05）；IGT、GDM組與正常對照組比較，IGT、GDM 組內相互比較，HbA1c和GSP異常率差異均有統計學意義（P＜0．05）；在特異度、靈敏度、暘性預測值和正確診斷指數4項指標比較中，GSP均優于HbA1c ，分彆為96．31％、89．78％、97．89％、91．94％；兩者聯閤檢測各指標值分彆為98．63％、90．27％、98．65％、93．00％，說明兩者聯閤檢測用于診斷GDM 更為準確；相關性分析錶明，正常對照組、IGT、GDM組的 HbA1c和GSP水平呈正相關（r分彆為0．536、0．506、0．665，P＜0．05）。結論 HbA1c和GSP水平可以作為診斷GDM的重要指標，聯閤檢測兩者對GDM的診斷具有重要意義。
목적：통과대임신당뇨병（GDM ）환자적당화혈홍단백（HbA1c）화당화혈청단백（GSP）수평변화적검측，탐토량자연합검측재GDM 진단중적중요의의。방법선취주원잉부，162례진단위임신기당뇨병（GDM조），94례당내량이상（IGT조），채용면역비탁법검측HbA1c ，채용과당알담람사서법검측GSP ，채용양화매법검측혈당；동시여156례정상잉부（정상대조조）검측지표비교。결과 IGT 조、GDM 조여정상대조조비교，GDM 조여IGT조비교，혈당、HbA1c화GSP수평균유통계학의의（P＜0．05）；IGT、GDM조여정상대조조비교，IGT、GDM 조내상호비교，HbA1c화GSP이상솔차이균유통계학의의（P＜0．05）；재특이도、령민도、양성예측치화정학진단지수4항지표비교중，GSP균우우HbA1c ，분별위96．31％、89．78％、97．89％、91．94％；량자연합검측각지표치분별위98．63％、90．27％、98．65％、93．00％，설명량자연합검측용우진단GDM 경위준학；상관성분석표명，정상대조조、IGT、GDM조적 HbA1c화GSP수평정정상관（r분별위0．536、0．506、0．665，P＜0．05）。결론 HbA1c화GSP수평가이작위진단GDM적중요지표，연합검측량자대GDM적진단구유중요의의。
Objective To investigate the important significance of the combined detection of glycosylated he‐moglobin(HbA1c) and glycosylated serum protein(GSP) in the diagnosis of gestational diabetes mellitus(GDM ) by detecting the changes of HbA1c and GSP levels in GDM patients .Methods The pregnant women inpatients in our hospital were selected ,including 162 cases of GDM and 94 cases of impaired glucose tolerance(IGT) .GSP was detec‐ted by adopting the fructosamine nitroblue tetrazolium method ,HbA1c was detected by the immunoturbidimetry and serum glucose was detected by oxidase method .The detection results were compared with those detected in 156 cases of normal pregnant women .Results The serum glucose ,HbA1c and GSP levels had statistically significant difference between the IGT and GDM groups with the normal control group ,and between the GDM group and IGT group(P<0 .05);the abnormal rate of HbA1c and GSP had statistically significant difference between the IGT and GDM groups with the normal control group ,and between the IGT and GDM groups(P<0 .05);GSP was superior to HbA1c in the comparison of 4 indicators for specificity ,sensitivity ,positive predictive value and correct diagnosis ,its specificity , sensitivity ,positive predictive value and correct diagnosis were 96 .31% ,89 .78% ,97 .89% and 91 .94% respectively ;but which of the their combined detection were 98 .63% ,90 .27% ,98 .65% and 93 .00% respectively ,indicating that the combined detection of these two indicators for the diagnosis of GDM was more accurate;the correlation analysis showed that in the HbA1c level was positively correlated with the GSP level in the normal control group ,IGT group and GDM group(r=0 .536 ,P<0 .05 ;r=0 .506 ,P<0 .05 ;r=0 .665 ,P<0 .05) .Conclusion The HbA1c and GSP levels can be used as the important indicators for the diagnosis of GDM and their combined detection has an important significance to the diagnosis of GDM .
