检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
22期
3364-3365
,共2页
陈祖翼%丁显平%景亚玲%文强%张顺%曹曼
陳祖翼%丁顯平%景亞玲%文彊%張順%曹曼
진조익%정현평%경아령%문강%장순%조만
宫颈癌%人乳头瘤病毒%变异
宮頸癌%人乳頭瘤病毒%變異
궁경암%인유두류병독%변이
cervical cancer%human papillomavirus%variation
目的:研究四川地区人乳头瘤病毒(HPV)的33 E6/E7基因变异情况,为HPV的防治提供分子水平的数据。方法用PCR方法扩增HPV阳性患者宫颈刷脱细胞中 HPV‐33 E6/E7基因,测序并与GenBank的参考序列对比寻找变异位点,对变异进行初步分析。结果与参考序列相比,成都地区 HPV‐33 E6基因变异率为56.00%(28/50),HPV‐33 E7基因变异率为54.00%(27/50)。结论 CINⅢ/CC样品中 HPV‐33 E6/E7序列变异程度比宫颈炎中更高,序列突变可能增加患宫颈癌风险。
目的:研究四川地區人乳頭瘤病毒(HPV)的33 E6/E7基因變異情況,為HPV的防治提供分子水平的數據。方法用PCR方法擴增HPV暘性患者宮頸刷脫細胞中 HPV‐33 E6/E7基因,測序併與GenBank的參攷序列對比尋找變異位點,對變異進行初步分析。結果與參攷序列相比,成都地區 HPV‐33 E6基因變異率為56.00%(28/50),HPV‐33 E7基因變異率為54.00%(27/50)。結論 CINⅢ/CC樣品中 HPV‐33 E6/E7序列變異程度比宮頸炎中更高,序列突變可能增加患宮頸癌風險。
목적:연구사천지구인유두류병독(HPV)적33 E6/E7기인변이정황,위HPV적방치제공분자수평적수거。방법용PCR방법확증HPV양성환자궁경쇄탈세포중 HPV‐33 E6/E7기인,측서병여GenBank적삼고서렬대비심조변이위점,대변이진행초보분석。결과여삼고서렬상비,성도지구 HPV‐33 E6기인변이솔위56.00%(28/50),HPV‐33 E7기인변이솔위54.00%(27/50)。결론 CINⅢ/CC양품중 HPV‐33 E6/E7서렬변이정도비궁경염중경고,서렬돌변가능증가환궁경암풍험。
Objective To investigate human papillomavirus(HPV)33 E6/E7 gene variation in Chengdu area to provide the molecular level data for the prevention and treatment of HPV infection .Methods The HPV‐33 E6/E7 genes in cervical exfoliated cells from the patients with HPV positive were amplified by PCR .The results were se‐quenced and compared with referencel sequence in GenBank for finding the mutant sites .Then the variations were preliminarily analyzed .Results Compared with the reference sequence ,the variation rate of HPV‐33 E6 in Chengdu area was 56 .00% (28/50) and which of HPV‐33 E7 was 54 .00% (27/50) .Conclusion The variation degree of HPV‐33 E6/E7 in CINⅢ /CC sample is higher than that in cervicitis ,the sequence mutations may increase the risk suffer‐ing from cervical cancer .