CAJ | 학술논문

目的：探讨非霍奇金淋巴瘤（NHL）患者中乙型肝炎（乙肝）病毒（HBV）的感染率。方法统计2012年9月至2014年12月住院的201例N H L确诊患者的乙肝5项标志物阳性率，并与388例同期住院的肺癌患者和325例体检中心健康体检者对比。结果201例NHL患者HBsAg阳性率和“小三阳”[HBsAg（＋）、HBeAb（＋）及HBcAb（＋）]发生率分别为16．9％和14．9％，明显高于肺癌患者（8．8％和8．2％）和健康体检者（5．2％和4．6％），差异均有统计学意义（P＜0．05）。NHL患者 HBsAb阳性率为45．3％，明显低于肺癌患者（57．2％）和健康体检者（55．4％），差异均有统计学意义（P＜0．05）。B细胞型 NHL的 HBsAg阳性率高于 T 细胞型NHL（P＜0．05），且HBsAb阳性率低于T细胞型NHL（P＜0．05），但性别、年龄的差异均无统计学意义（P＞0．05）。59例 NHL患者HBV DNA阳性率为27．1％，其中 HBsAg阳性患者阳性率为47．1％，HBsAg（－）伴HBcAb（＋）的25例患者中有1例（4．0％）HBV DNA阳性。结论 NHL患者的 HBV感染率高于肺癌患者和健康体检人群，特别是B细胞型NHL患者。NHL与 HBV感染存在一定相关性，不能忽视NHL患者 HBV隐匿性感染的情况。
목적：탐토비곽기금림파류（NHL）환자중을형간염（을간）병독（HBV）적감염솔。방법통계2012년9월지2014년12월주원적201례N H L학진환자적을간5항표지물양성솔，병여388례동기주원적폐암환자화325례체검중심건강체검자대비。결과201례NHL환자HBsAg양성솔화“소삼양”[HBsAg（＋）、HBeAb（＋）급HBcAb（＋）]발생솔분별위16．9％화14．9％，명현고우폐암환자（8．8％화8．2％）화건강체검자（5．2％화4．6％），차이균유통계학의의（P＜0．05）。NHL환자 HBsAb양성솔위45．3％，명현저우폐암환자（57．2％）화건강체검자（55．4％），차이균유통계학의의（P＜0．05）。B세포형 NHL적 HBsAg양성솔고우 T 세포형NHL（P＜0．05），차HBsAb양성솔저우T세포형NHL（P＜0．05），단성별、년령적차이균무통계학의의（P＞0．05）。59례 NHL환자HBV DNA양성솔위27．1％，기중 HBsAg양성환자양성솔위47．1％，HBsAg（－）반HBcAb（＋）적25례환자중유1례（4．0％）HBV DNA양성。결론 NHL환자적 HBV감염솔고우폐암환자화건강체검인군，특별시B세포형NHL환자。NHL여 HBV감염존재일정상관성，불능홀시NHL환자 HBV은닉성감염적정황。
Objective To investigate the hepatitis B virus (HBV ) infection rate in the patients with non‐Hodgkin lymphoma(NHL) .Methods The positive rates of HBV 5 markers in 201 patients with NHL admitted to our hospital from September 2012 to December 2014 were performed the statistics and compared with those in 388 contemporaneous inpatients with lung cancer and 325 healthy persons undergoing the physical examination in the physical examination center .Results The HBsAg‐positive rate and the simultaneously positive rate of HBsAg ,HBe‐Ab and HBcAb in 201 cases of NHL were 16 .9% and 14 .9% respectively ,which were higher than those in the lung cancer patients(8 .8% and 8 .2% ) and healthy persons undergoing the physical examination(5 .2% and 4 .6% ) ,the differences were statistically significant(P< 0 .05) .The positive rate of anti‐HBsAb was 45 .3% in the NHL pa‐tients ,which was significantly lower than 57 .2% in the lung cancer patients and 55 .4% in healthy persons ,the differences were statistically significant(P<0 .05) .Compared with the T‐cell NHL ,the B‐cell NHL had significantly higher positive rate of HBsAg and lower positive rate of HBsAb ,but there were no statistically significant differences in sex and age(P>0 .05) .The HBV DNA positive rate was 27 .1% in 59 cases of NHL ,and was 47 .1% in 34 cases of HBsAg‐positive NHL ,while 1 case(4 .0% ) in 25 cases of HBsAg‐negative and HBcAb‐positive NHL .Conclusion The infection rate of HBV in NHL patients is significantly higher than that in the lung cancer patients and healthy persons ,especially in the B‐cell NHL .There is a certain correlation between NHL and HBV infection ,and the occult HBV infection in NHL patients can not be ignored .