CAJ | 학술논문

目的：探讨酒精依赖患者的血尿酸水平，分析其与酒精性精神障碍、认知功能的相关性。方法选择酒精依赖住院患者97例作为研究对象，选择同期100例健康者作为对照。两组受检者抽取空腹静脉血3 m L ，应用日立7600‐D全自动生化分析仪测定血尿酸水平，分析血尿酸水平与酒精依赖及其精神障碍的关系，用线性回归分析酒精依赖与认知功能的关系。结果酒精依赖患者血尿酸水平明显高于健康对照组（P＜0．05），伴有精神障碍组血尿酸水平明显高于无精神障碍组（P＜0．05），血尿酸水平与认知功能相关测试无明显相关性（P＞0．05）。结论酒精依赖代偿性提高血尿酸水平，启动保护性机制，代偿机制又导致脑组织核苷酸的降低，损害神经细胞和信号传导。
목적：탐토주정의뢰환자적혈뇨산수평，분석기여주정성정신장애、인지공능적상관성。방법선택주정의뢰주원환자97례작위연구대상，선택동기100례건강자작위대조。량조수검자추취공복정맥혈3 m L ，응용일립7600‐D전자동생화분석의측정혈뇨산수평，분석혈뇨산수평여주정의뢰급기정신장애적관계，용선성회귀분석주정의뢰여인지공능적관계。결과주정의뢰환자혈뇨산수평명현고우건강대조조（P＜0．05），반유정신장애조혈뇨산수평명현고우무정신장애조（P＜0．05），혈뇨산수평여인지공능상관측시무명현상관성（P＞0．05）。결론주정의뢰대상성제고혈뇨산수평，계동보호성궤제，대상궤제우도치뇌조직핵감산적강저，손해신경세포화신호전도。
Objective To investigate the serum uric acid level in the patients with alcohol dependence ,and to analyze its correlation with the alcoholic sychosis and cognitive function .Methods 97 inpatients with alcohol depend‐ence were selected as the study subjects .The contemporaneous 100 healthy individuals undergoing the physical exam‐ination were taken as the controls .The fasting venous blood 3mL in the two groups was collected and detected the blood uric acid level by using the Hitachi 7600‐D biochemical analyzer .The relationship between the uric acid level with the mental disorders and alcoholic dependence was analyzed by using the t‐test .The linear regression was adopt‐ed to analyze the relationship between alcohol dependence and the cognitive function .Results The uric acid level in alcohol dependent patients was significantly higher than that in the healthy control group(P< 0 .05) ,the uric acid level in the mental disorder group was significantly higher than that in the non‐mental disorder group(P<0 .05) , there was no significant correlation between the cognitive function and blood uric acid level(P>0 .05) .Conclusion Alcoholic dependence compensatorily increases the serum uric acid level ,activates the protective mechanism ,the com‐pensatory mechanism also reduces brain tissue nucleotides level and damages the nerve cells and signal transduction .