检验医学与临床
檢驗醫學與臨床
검험의학여림상
Laboratory Medicine and Clinic
2015年
22期
3314-3317
,共4页
宫颈癌前病变%HPV L1壳蛋白%P16
宮頸癌前病變%HPV L1殼蛋白%P16
궁경암전병변%HPV L1각단백%P16
cervical intraepithelial neoplasia%HPV L1 capsid protein%P16 protein
目的：研究HPV L1壳蛋白与P16蛋白联合运用在宫颈癌前病变诊断中的临床意义及对转归的预测价值。方法对208例TCT异常且HR‐HPV阳性的患者进行宫颈活检并根据病理结果分组，同时检测其HPV L1壳蛋白和P16蛋白并根据两种抗体表达情况分为4组，并对其中随访到的155例患者进行 HPV转阴分析。结果 HPV L1壳蛋白和P16蛋白在不同级别宫颈组织中的表达均不同，CINⅠ组的L1壳蛋白阳性率高于其他CIN组（P＜0．01），≥CINⅢ组的P16蛋白阳性率高于其他3组（P＜0．01）；随访病例中 HPV L1壳蛋白（＋）／P16蛋白（－）的转阴率高，尤其在CINⅠ患者中该组高于其他几组（P＜0．05）。结论 HPV L1壳蛋白与P16蛋白联合检测可成为诊断及预测宫颈病变的一个有效指标。
目的：研究HPV L1殼蛋白與P16蛋白聯閤運用在宮頸癌前病變診斷中的臨床意義及對轉歸的預測價值。方法對208例TCT異常且HR‐HPV暘性的患者進行宮頸活檢併根據病理結果分組，同時檢測其HPV L1殼蛋白和P16蛋白併根據兩種抗體錶達情況分為4組，併對其中隨訪到的155例患者進行 HPV轉陰分析。結果 HPV L1殼蛋白和P16蛋白在不同級彆宮頸組織中的錶達均不同，CINⅠ組的L1殼蛋白暘性率高于其他CIN組（P＜0．01），≥CINⅢ組的P16蛋白暘性率高于其他3組（P＜0．01）；隨訪病例中 HPV L1殼蛋白（＋）／P16蛋白（－）的轉陰率高，尤其在CINⅠ患者中該組高于其他幾組（P＜0．05）。結論 HPV L1殼蛋白與P16蛋白聯閤檢測可成為診斷及預測宮頸病變的一箇有效指標。
목적：연구HPV L1각단백여P16단백연합운용재궁경암전병변진단중적림상의의급대전귀적예측개치。방법대208례TCT이상차HR‐HPV양성적환자진행궁경활검병근거병리결과분조，동시검측기HPV L1각단백화P16단백병근거량충항체표체정황분위4조，병대기중수방도적155례환자진행 HPV전음분석。결과 HPV L1각단백화P16단백재불동급별궁경조직중적표체균불동，CINⅠ조적L1각단백양성솔고우기타CIN조（P＜0．01），≥CINⅢ조적P16단백양성솔고우기타3조（P＜0．01）；수방병례중 HPV L1각단백（＋）／P16단백（－）적전음솔고，우기재CINⅠ환자중해조고우기타궤조（P＜0．05）。결론 HPV L1각단백여P16단백연합검측가성위진단급예측궁경병변적일개유효지표。
Objective To evaluate the clinical significance of the combination detection of human papillomavir‐us(HPV) L1 capsid protein and p16 protein in the diagnosis of cervical precancerous lesion and its predictive value to disease outcome .Methods 208 cases of abnormal in thinprep cytologic test and high risk(HR)‐HPV positive were performed the cervical biopsy and grouped according to the histopathologic test .Meanwhile ,these cases were detected the HPV L1 capsid protein and the p16 protein and then divided into 4 groups according to the expression situation of these two kinds of antibody .Among them ,155 followed up cases were performed the analysis of HPV negative con‐version .Results The expression of L1 and P16 was different among different grades of cervical tissues ,the positive rate of L1 in the cervical intraepithelial neoplasia(CIN)Ⅰ group was higher than that of other CIN groups(P<0 .01) and the positive rate of P16 in the ≥CINⅢ group was higher than that in the other 3 groups(P<0 .01) .Among the follow‐up cases ,the negative conversion rate in the HPV L1(+ )/P16(-) was higher ,especially which in the CINⅠgroup was higher than other groups(P<0 .05) .Conclusion The combined detection of HPV L1 capsid protein and P16 protein can be used as an effective indicator in the diagnosis and prediction of cervical lesions .
