CAJ | 학술논문

目的：探讨低强度颈动脉压力感受器刺激（LL-CBS）对异丙肾上腺素诱导的室性心律失常（VAs）的影响。方法正常成年杂种犬20只，随机分为对照组和LL-CBS组各10只，均安置颈动脉窦刺激电极，监测血压、心率。 LL-CBS组于VAs诱发前1 h开始LL-CBS直至实验结束，对照组给予假性LL-CBS，分别测量基线时和刺激1 h后心室有效不应期（ ERP）。心室ERP测量结束后，保持颈动脉窦刺激，静置半小时，静脉注射异丙肾上腺素，诱发3个VAs事件。分别记录3个VAs事件时VAs发生次数，首个室性早搏出现的时间、室性早搏次数、室性心动过速（简称室速）次数及持续时间。结果两组在基线状态、刺激1h和注射异丙肾上腺素后血压、心率比较均无统计学差异（P均＞0．05）。 LL-CBS组、对照组基线时心室ERP分别为（165±5）、（168±8）ms（P＞0．05），刺激1 h时分别为（181±7）、（162±7）ms（P＜0．05）。在3个VAs事件过程中，LL-CBS组发生Vas次数均少于对照组（P均＜0．05）；LL-CBS组首次室性早搏出现的时间为刺激后341（512，224） s、对照组为刺激后215（327，90） s，室性早搏次数分别为52（83，20）、107（162，54）次，室速次数分别为2．3（6．7，0．5）、5．5（9．3，2．4）次，两组比较P均＜0．05。结论 LL-CBS刺激可抑制异丙肾上腺素诱发的VAs发生，且不影响血压、心率。
목적：탐토저강도경동맥압력감수기자격（LL-CBS）대이병신상선소유도적실성심률실상（VAs）적영향。방법정상성년잡충견20지，수궤분위대조조화LL-CBS조각10지，균안치경동맥두자격전겁，감측혈압、심솔。 LL-CBS조우VAs유발전1 h개시LL-CBS직지실험결속，대조조급여가성LL-CBS，분별측량기선시화자격1 h후심실유효불응기（ ERP）。심실ERP측량결속후，보지경동맥두자격，정치반소시，정맥주사이병신상선소，유발3개VAs사건。분별기록3개VAs사건시VAs발생차수，수개실성조박출현적시간、실성조박차수、실성심동과속（간칭실속）차수급지속시간。결과량조재기선상태、자격1h화주사이병신상선소후혈압、심솔비교균무통계학차이（P균＞0．05）。 LL-CBS조、대조조기선시심실ERP분별위（165±5）、（168±8）ms（P＞0．05），자격1 h시분별위（181±7）、（162±7）ms（P＜0．05）。재3개VAs사건과정중，LL-CBS조발생Vas차수균소우대조조（P균＜0．05）；LL-CBS조수차실성조박출현적시간위자격후341（512，224） s、대조조위자격후215（327，90） s，실성조박차수분별위52（83，20）、107（162，54）차，실속차수분별위2．3（6．7，0．5）、5．5（9．3，2．4）차，량조비교P균＜0．05。결론 LL-CBS자격가억제이병신상선소유발적VAs발생，차불영향혈압、심솔。
Objective To investigate the effects of low-level carotid baroreceptor stimulation ( LL-CBS) on isoproter-enol-induced ventricular arrhythmias ( VAs) .Methods Twenty adult mongrel dogs were randomly divided into the LL-CBS group (n=10) and the control group (n=10).The stimulating electrode of carotid artery was placed to monitor the blood pressure ( BP) and heart rate ( HR) .After 1 hour of LL-CBS the VAs was induced by isoproterenol in the LL-CBS group.The stimulation was not stopped until the experiment was over .The false LL-CBS was given to the dogs in the con-trol group.The ventricular effective refractory period ( ERP) during baseline and 1 hour.Each dog underwent three in-duction episodes.The occurrence time of first arrhythmic beat, the number of ventricular premature beat, the number and the duration of ventricular tachycardia were measured and analyzed .Results The values of BP and HR were not signifi-cantly different between the two groups during baseline , 1 hour and intravenous isoproterenol ( all P>0 .05 ) .The ERP was (165 ±5) ms in the LL-CBS group and (168 ±8) ms in the control group during baseline (P>0.05), and the ERP was respectively (181 ±7) ms and (162 ±7) ms in the LL-CBS group and control group 1 hour after stimulation (P<0.05).The occurrence of VAs in the LL-CBS group was less than that in the control group every time (all P<0.05).The occurrence time of first ventricular premature beat of the LL-CBS group was 341 (512, 224) s, and 215 (327, 90) s in the control group;the number of premature ventricular contractions was 52 (83, 20), and 107 (162, 54) in the control group;and the number of ventricular tachycardia was 2.3 (6.7, 0.5), and 5.5 (9.3, 2.4) in the control group (all P<0.05).Conclusion LL-CBS inhibits the occurrence of isoproterenol-induced VAs without chan-ges of BP and HR .