CAJ | 학술논문

目的探讨中药制剂解毒饮对骨创伤术后炎症反应的影响. 方法选择2013年6月-2014年5月收治的100例骨创伤患者,按随机数字表法分为试验组和对照组,每组50例.试验组服用中药解毒饮,对照组服用5 g/ml淡红糖水,均连续治疗7d,观察患者术后1 d(T1)、3d(T3)、5 d(T5)、7 d(T7)外周血白细胞(WBC)计数、血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)变化、全身炎症反应综合征(SIRS)发病率及SIRS评分变化. 结果试验组和对照组T1时WBC计数、TNF-α、IL-6均明显升高,但差异均无统计学意义(P＞0.05);两组T3、T5、T7时以上指标均有所下降,但试验组较对照组下降幅度大(P＜0.05).T1时SIRS发生率试验组(74％)和对照组(66％)差异无统计学意义(P＞0.05),T3、T5、T7时差异均有统计学意义(P＜0.05).SIRS评分T1时试验组(6.2±1.2)分和对照组(6.5±1.3)分差异无统计学意义(P＞0.05),T3、T5、T7时差异均有统计学意义(P＜0.05). 结论解毒饮能抑制炎症的过度反应,降低外周血炎症水平,降低SIRS发生率,对骨创伤后全身炎症反应疗效良好.
목적 탐토중약제제해독음대골창상술후염증반응적영향. 방법 선택2013년6월-2014년5월수치적100례골창상환자,안수궤수자표법분위시험조화대조조,매조50례.시험조복용중약해독음,대조조복용5 g/ml담홍당수,균련속치료7d,관찰환자술후1 d(T1)、3d(T3)、5 d(T5)、7 d(T7)외주혈백세포(WBC)계수、혈청종류배사인자-α(TNF-α)、백세포개소-6(IL-6)변화、전신염증반응종합정(SIRS)발병솔급SIRS평분변화. 결과 시험조화대조조T1시WBC계수、TNF-α、IL-6균명현승고,단차이균무통계학의의(P＞0.05);량조T3、T5、T7시이상지표균유소하강,단시험조교대조조하강폭도대(P＜0.05).T1시SIRS발생솔시험조(74％)화대조조(66％)차이무통계학의의(P＞0.05),T3、T5、T7시차이균유통계학의의(P＜0.05).SIRS평분T1시시험조(6.2±1.2)분화대조조(6.5±1.3)분차이무통계학의의(P＞0.05),T3、T5、T7시차이균유통계학의의(P＜0.05). 결론 해독음능억제염증적과도반응,강저외주혈염증수평,강저SIRS발생솔,대골창상후전신염증반응료효량호.
Objective To evaluate the effect of Jieduyin decoction on inflammatory response after trauma and orthopedic surgery.Methods The study enrolled 100 patients undergone trauma and orthopedic surgery between June 2013 and May 2014.All the subjects were assigned to study group and control group with 50 cases for each according to the random number table.In study group the subject had Jieduyin decoction,but 5 g/m1 sugar water in control group for 7 consecutive days.Parameters measured after operation included white blood cell (WBC) count,serum tumor necrosis factor-α (TNF-α),interlukin-6 (IL-6),incidence of systemic inflammatory response syndrome (SIRS) and SIRS score.Results Notable increases in WBC count,TNF-α as well as IL-6 were seen in both groups at postoperative 1 day,but the differences between the two groups were all insignificant (P ＞ 0.05).These parameters presented some decreases at postoperative 3,5 and 7 days,greater in study group than in control group (P ＜ 0.05).SIRS incidence and score did not differ significantly between the two groups at postoperative 1 day (P ＞ 0.05),but there were significant differences at postoperative 3,5 and 7 days (P ＜ 0.05).Conclusion Jieduyin can ameliorate the excessive inflammatory response,reduce inflammatory levels of the peripheral blood,and decrease the incidence of SIRS,which indicates a good therapy for the systemic inflammatory response following trauma and orthopedic surgery.