广州化工
廣州化工
엄주화공
Guangzhou Chemical Industry
2015年
21期
5-9
,共5页
四氢喹啉%aza-Diels-Alder反应%环加成反应
四氫喹啉%aza-Diels-Alder反應%環加成反應
사경규람%aza-Diels-Alder반응%배가성반응
tetrahydroquinolines%aza-Diels-Alder reaction%cycloaddition
四氢喹啉类化合物具有广泛的生物活性，并且也是一类重要的染料中间体。综述了近几年由N-芳基亚胺与亲双烯体经aza-Diels-Alder反应合成四氢喹啉的反应，以及由羰基化合物、胺和烯醇醚“一锅法”合成四氢喹啉的进展。分析比较了路易斯酸催化、阳离子自由基催化、其他酸催化合成等不同合成方法的优缺点。由羰基化合物、胺和烯醇醚“一锅法”构建四氢喹啉骨架更加简便，具有广阔的发展前景。
四氫喹啉類化閤物具有廣汎的生物活性，併且也是一類重要的染料中間體。綜述瞭近幾年由N-芳基亞胺與親雙烯體經aza-Diels-Alder反應閤成四氫喹啉的反應，以及由羰基化閤物、胺和烯醇醚“一鍋法”閤成四氫喹啉的進展。分析比較瞭路易斯痠催化、暘離子自由基催化、其他痠催化閤成等不同閤成方法的優缺點。由羰基化閤物、胺和烯醇醚“一鍋法”構建四氫喹啉骨架更加簡便，具有廣闊的髮展前景。
사경규람류화합물구유엄범적생물활성，병차야시일류중요적염료중간체。종술료근궤년유N-방기아알여친쌍희체경aza-Diels-Alder반응합성사경규람적반응，이급유탄기화합물、알화희순미“일과법”합성사경규람적진전。분석비교료로역사산최화、양리자자유기최화、기타산최화합성등불동합성방법적우결점。유탄기화합물、알화희순미“일과법”구건사경규람골가경가간편，구유엄활적발전전경。
Tetrahydroquinoline derivatives have a wide range of biological activities, and are also a kind of important dye intermediates. The reactions for the synthesis of tetrahydroquinoline derivatives by aza-Diels-Alder reactions between N-arylimines and dienophiles were reviewed. New developments in the “one-pot” synthesis of tetrahydroquinoline derivatives from the carbonyl compounds, amines, and enol ethers were also reviewed. Different synthetic methods, including Lewis acid catalysis, cation radical catalysis, and other acid catalysis were compared and discussed. Forming tetrahydroquinoline skeletons by “one-pot” synthesis from the carbonyl compounds, amines, and enol ethers is easier, and has broad prospects for development.
