CAJ | 학술논문

原发性高血压( Essential Hypertension ，EH )是危害人类健康的主要疾病之一，也是导致脑卒中、冠心病、心功能不全、肾脏疾病等的主要因素。EH是一种由遗传因素和环境因素共同作用的疾病，本文试从一氧化氮( Nitric Oxide ，NO )与高血压的关系、eNOS基因结构与多态性、eNOS基因G894T多态性与EH的关系方面就一氧化氮合酶( Nitric Oxide Synthase ，NOS )基因多态性与高血压病关系研究进展进行综述。
원발성고혈압( Essential Hypertension ，EH )시위해인류건강적주요질병지일，야시도치뇌졸중、관심병、심공능불전、신장질병등적주요인소。EH시일충유유전인소화배경인소공동작용적질병，본문시종일양화담( Nitric Oxide ，NO )여고혈압적관계、eNOS기인결구여다태성、eNOS기인G894T다태성여EH적관계방면취일양화담합매( Nitric Oxide Synthase ，NOS )기인다태성여고혈압병관계연구진전진행종술。
Essential Hypertension (EH) is one of the main diseases threatening human health ,it is also a major fac-tor inducing stroke,coronary heart disease,cardiac insufficiency,and kidney diseases.EH is a disease resulting fromge-netic factors and environmental factors.This paper tries to summarize the relationship between nitric oxide synthase gene polymorphism and hypertension fromthe aspects of relationship between nitric oxide (NO) and hypertension ,be-tween eNOS genetic structure and polymorphism,polymorphism of G 894Tof eNOS gene,and EH.