CAJ | 학술논문

目的：探讨急性脑梗死患者血清巨噬细胞移动抑制因子(MIF)、基质金属蛋白酶-9(MMP-9)、超敏C-反应蛋白(hs-CRP)水平与病情严重程度的相关性。方法急性脑梗死患者101例根据美国国立卫生研究院卒中量表(NIHSS)评分分为轻型脑梗死组(A组，NIHSS评分<4分，n=38)、中型脑梗死组(B组，NIHSS评分4~15分，n=36)和重型脑梗死组(C组，NIHSS评分>15分，n=27)；同期住院44例有动脉粥样硬化危险因素非急性脑梗死患者为对照组(D组)。酶联免疫吸附法测定血清中MIF、MMP-9水平，免疫散射比浊法检测hs-CRP水平。结果各组间MIF、MMP-9及hs-CRP水平从高到低依次为C组、B组、A组、D组(P<0.05)。MIF与MMP-9(r=0.301, P<0.01)和hs-CRP (r=0.309, P<0.001)呈正相关。结论急性脑梗死患者血清MIF、MMP-9、hs-CRP水平升高，可能预测动脉粥样硬化斑块稳定性。
목적：탐토급성뇌경사환자혈청거서세포이동억제인자(MIF)、기질금속단백매-9(MMP-9)、초민C-반응단백(hs-CRP)수평여병정엄중정도적상관성。방법급성뇌경사환자101례근거미국국립위생연구원졸중량표(NIHSS)평분분위경형뇌경사조(A조，NIHSS평분<4분，n=38)、중형뇌경사조(B조，NIHSS평분4~15분，n=36)화중형뇌경사조(C조，NIHSS평분>15분，n=27)；동기주원44례유동맥죽양경화위험인소비급성뇌경사환자위대조조(D조)。매련면역흡부법측정혈청중MIF、MMP-9수평，면역산사비탁법검측hs-CRP수평。결과각조간MIF、MMP-9급hs-CRP수평종고도저의차위C조、B조、A조、D조(P<0.05)。MIF여MMP-9(r=0.301, P<0.01)화hs-CRP (r=0.309, P<0.001)정정상관。결론급성뇌경사환자혈청MIF、MMP-9、hs-CRP수평승고，가능예측동맥죽양경화반괴은정성。
Objective To investigate the relationship of serum levels of macrophage migration inhibitory factor (MIF), matrix metallo-proteinase-9 (MMP-9), hypersensitive C-reactive protein (hs-CRP) with the severity of acute cerebral infarction (ACI). Methods 101 pa-tients with ACI were envolved and divided into 3 groups according to the scores of National Institute of Health Stroke Scale (NIHSS):mild group (group A, n=38, NIHSS score<4), moderate group (group B, n=36, NIHSS score 4-15) and severe group (group C, n=27, NIHSS score>15). Meanwhile, 44 non-ACI inpatients with atherosclerosis were included as control group (group D). Their serum MIF and MMP-9 were detected with ELISA, and hs-CRP with immunoturbidimety. Results The levels of serum MIF, MMP-9 and hs-CRP ranged from more to less as groups C, B, A and D (P<0.05). There was positive correlation of MIF with MMP-9 (r=0.301, P<0.01) and hs-CRP (r=0.309, P<0.001). Conclusion Serum MIF, MMP-9 and hs-CRP levels increased with the severity in ACI patients, which may be prediction of athero-sclerotic plaque instability.