CAJ | 학술논문

目的：探讨肾小球滤过率（ eGFR）与老年冠心病患者心功能的关系。方法305例老年冠心病患者，行心脏彩色多普勒超声测量左房内径及左室射血分数，采用改良美国肾脏病膳食改良实验（ MDRD）公式估算eGFR，分析eGFR与老年冠心病患者心功能的关系。结果305例患者中，eGFR正常92例，eGFR轻度减低168例，eGFR中重度减低45例；3组患者年龄比较，差异有统计学意义（P＜0．05），呈eGFR中重度减低组年龄＞eGFR轻度减低组年龄＞eGFR正常组年龄（P＜0．05）。 eGFR轻度减低组、eGFR 中重度减低组的左房内径均大于 eGFR 正常组，射血分数均低于肾功能正常组（P＜0．05）。 eGFR与左房内径呈负相关性（P＜0．05），与左室射血分数呈正相关性（P＜0．05）。结论肾小球滤过率与老年冠心病患者心功能相关，是预测其心功能下降的重要指标。
목적：탐토신소구려과솔（ eGFR）여노년관심병환자심공능적관계。방법305례노년관심병환자，행심장채색다보륵초성측량좌방내경급좌실사혈분수，채용개량미국신장병선식개량실험（ MDRD）공식고산eGFR，분석eGFR여노년관심병환자심공능적관계。결과305례환자중，eGFR정상92례，eGFR경도감저168례，eGFR중중도감저45례；3조환자년령비교，차이유통계학의의（P＜0．05），정eGFR중중도감저조년령＞eGFR경도감저조년령＞eGFR정상조년령（P＜0．05）。 eGFR경도감저조、eGFR 중중도감저조적좌방내경균대우 eGFR 정상조，사혈분수균저우신공능정상조（P＜0．05）。 eGFR여좌방내경정부상관성（P＜0．05），여좌실사혈분수정정상관성（P＜0．05）。결론신소구려과솔여노년관심병환자심공능상관，시예측기심공능하강적중요지표。
Objective To explore the association between estimated glomerular filtration rate ( eGFR ) and cardiac function in elderly patients with coronary heart disease .Methods Three hundred and five elderly patients with coronary heart disease underwent color Doppler echocardiography for the measurement of left ventricular diameter and left ventricular ejection fraction .The eGFR of all patients were assessed using the formula of Modification of Diet in Renal Disease ( MDRD) .And the association between eGFR and cardiac function in elderly patients with coronary heart disease was analyzed .Results Of 305 patients,there were 92 with normal eGFR,168 with mild eGFR reduction and 45 with morderate-severe eGFR reduction.There was significant difference in age among three groups (P<0.05),and it showed that the age in the morderate-severe eGFR reduction group >the age in the mild eGFR reduction group >the age in the normal eGFR group(P<0.05).Compared to normal eGFR group,mild eGFR reduction group or morderate-severe eGFR reduction group had larger left ventricular diameter and less left ventricular ejection fraction(P<0.05).eGFR negatively correlated with left ventricular diameter,but positively correlated with left ventricular ejection fraction (P<0.05).Conclusion eGFR is associated with cardiac function in elderly patients with coronary artery disease ,and is an important index for predicting the decline of cardiac function .