广西医学
廣西醫學
엄서의학
Guangxi Medical Journal
2015年
9期
1278-1279,1285
,共3页
黄月艳%李清锋%潘红飞%李强%唐汉庆%黄云峰%游金勇%黄肯
黃月豔%李清鋒%潘紅飛%李彊%唐漢慶%黃雲峰%遊金勇%黃肯
황월염%리청봉%반홍비%리강%당한경%황운봉%유금용%황긍
缺氧缺血性脑病%维生素E%维生素C%新生儿
缺氧缺血性腦病%維生素E%維生素C%新生兒
결양결혈성뇌병%유생소E%유생소C%신생인
Hypoxic-ischemic encephalopathy%Vitamin E%Vitamin C%Newborn
目的:观察维生素E联合维生素C辅助治疗新生儿缺氧缺血性脑病( HIE)的临床效果。方法 HIE患儿90例,按随机数字表法分为治疗组48例,对照组42例。两组均给予常规治疗,治疗组在常规治疗的基础上联合予口服维生素E及静脉滴注维生素C,均治疗2周。观察两组治疗前后血清超氧化物歧化酶( SOD)、谷胱甘肽过氧化物酶( GSH-Px)、丙二醛(MDA)水平及临床疗效。结果治疗组治疗后SOD、GSH-Px水平明显升高,而MDA水平明显下降(P<0.05),而对照组治疗前后上述指标无变化(P>0.05)。治疗组的总有效率为75.0%,对照组的总有效率为61.9%,治疗组疗效优于对照组(P<0.05)。结论维生素E联合维生素C辅助治疗HIE获得较好的临床效果,其治疗作用可能通过抗氧化途径实现。
目的:觀察維生素E聯閤維生素C輔助治療新生兒缺氧缺血性腦病( HIE)的臨床效果。方法 HIE患兒90例,按隨機數字錶法分為治療組48例,對照組42例。兩組均給予常規治療,治療組在常規治療的基礎上聯閤予口服維生素E及靜脈滴註維生素C,均治療2週。觀察兩組治療前後血清超氧化物歧化酶( SOD)、穀胱甘肽過氧化物酶( GSH-Px)、丙二醛(MDA)水平及臨床療效。結果治療組治療後SOD、GSH-Px水平明顯升高,而MDA水平明顯下降(P<0.05),而對照組治療前後上述指標無變化(P>0.05)。治療組的總有效率為75.0%,對照組的總有效率為61.9%,治療組療效優于對照組(P<0.05)。結論維生素E聯閤維生素C輔助治療HIE穫得較好的臨床效果,其治療作用可能通過抗氧化途徑實現。
목적:관찰유생소E연합유생소C보조치료신생인결양결혈성뇌병( HIE)적림상효과。방법 HIE환인90례,안수궤수자표법분위치료조48례,대조조42례。량조균급여상규치료,치료조재상규치료적기출상연합여구복유생소E급정맥적주유생소C,균치료2주。관찰량조치료전후혈청초양화물기화매( SOD)、곡광감태과양화물매( GSH-Px)、병이철(MDA)수평급림상료효。결과치료조치료후SOD、GSH-Px수평명현승고,이MDA수평명현하강(P<0.05),이대조조치료전후상술지표무변화(P>0.05)。치료조적총유효솔위75.0%,대조조적총유효솔위61.9%,치료조료효우우대조조(P<0.05)。결론유생소E연합유생소C보조치료HIE획득교호적림상효과,기치료작용가능통과항양화도경실현。
Objective To observe the clinical efficacy of adjuvant therapy of vitamin E and vitamin C on newborn with hypoxic-ischemic encephalopathy(HIE).Methods Ninety newborns with HIE were divided into treatment group(n=48) and control group(n=42) by random number table .The two groups were given conventional therapy .Treatment group were administrated vitamin E orally and vitamin C intravenously based on the conventional therapy .The therapeutical duration was two weeks in both groups .Before and after treatment ,the serum levels of superoxide dismutase ( SOD) ,glutathione peroxidase ( GSH-Px) and malondiadehyde ( MDA) as well as the clinical efficacy were observed in the two groups .Results The serum levels of SOD and GSH-Px increased significantly while the serum level of MDA decreased significantly in the treatment group after treatment (P<0.05),but no changes in the levels of SOD,GSH-Px and MDA were observed in the control group after treatment(P>0.05).The total effective rates of treatment group and control group were 75.0% and 61.9%,respectively,and the efficacy of treatment group was superior to that of control group ( P<0.05).Conclusion The adjuvant therapy of vitamin E and vitamin C obtains a good efficacy on HIE .And it might take effect by the way of antioxidantion .