广西医学
廣西醫學
엄서의학
Guangxi Medical Journal
2015年
9期
1243-1245
,共3页
糖尿病周围神经病变%2型糖尿病%初诊%危险因素
糖尿病週圍神經病變%2型糖尿病%初診%危險因素
당뇨병주위신경병변%2형당뇨병%초진%위험인소
Diabetic peripheral neuropathy%Type 2 diabetes mellitus%Newly diagnosed%Risk factor
目的：探讨初诊2型糖尿病（T2DM）患者并发糖尿病周围神经病变（DPN）的危险因素。方法170例初诊T2DM患者，根据有无自觉症状及神经传导速度测定有无异常分为无DPN组60例、DPN组110例。将体重指数（ BMI）、血压、入院时随机血糖（RBG）、空腹C肽（FCP）、糖负荷后2小时C肽（2hCP）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、尿酸（UA）、晨尿微量白蛋白／肌酐（UACR）等指标进行单因素分析，对有统计学意义的因素进行多因素logistic非条件回归分析。结果170例初诊T2DM患者DPN的患病率为64．7％。 DPN组年龄、RBG、UACR、HbA1 c高于无DPN组（ P＜0．05）。多因素logistic非条件回归分析显示，年龄、UACR、HbA1c为初诊T2DM患者发生并发DPN的危险因素（P＜0．05）。结论初诊T2DM患者易并发DPN，年龄、HbA1c、UACR为初诊T2DM患者发生DPN的危险因素。
目的：探討初診2型糖尿病（T2DM）患者併髮糖尿病週圍神經病變（DPN）的危險因素。方法170例初診T2DM患者，根據有無自覺癥狀及神經傳導速度測定有無異常分為無DPN組60例、DPN組110例。將體重指數（ BMI）、血壓、入院時隨機血糖（RBG）、空腹C肽（FCP）、糖負荷後2小時C肽（2hCP）、糖化血紅蛋白（HbA1c）、總膽固醇（TC）、甘油三酯（TG）、低密度脂蛋白膽固醇（LDL-C）、高密度脂蛋白膽固醇（HDL-C）、尿痠（UA）、晨尿微量白蛋白／肌酐（UACR）等指標進行單因素分析，對有統計學意義的因素進行多因素logistic非條件迴歸分析。結果170例初診T2DM患者DPN的患病率為64．7％。 DPN組年齡、RBG、UACR、HbA1 c高于無DPN組（ P＜0．05）。多因素logistic非條件迴歸分析顯示，年齡、UACR、HbA1c為初診T2DM患者髮生併髮DPN的危險因素（P＜0．05）。結論初診T2DM患者易併髮DPN，年齡、HbA1c、UACR為初診T2DM患者髮生DPN的危險因素。
목적：탐토초진2형당뇨병（T2DM）환자병발당뇨병주위신경병변（DPN）적위험인소。방법170례초진T2DM환자，근거유무자각증상급신경전도속도측정유무이상분위무DPN조60례、DPN조110례。장체중지수（ BMI）、혈압、입원시수궤혈당（RBG）、공복C태（FCP）、당부하후2소시C태（2hCP）、당화혈홍단백（HbA1c）、총담고순（TC）、감유삼지（TG）、저밀도지단백담고순（LDL-C）、고밀도지단백담고순（HDL-C）、뇨산（UA）、신뇨미량백단백／기항（UACR）등지표진행단인소분석，대유통계학의의적인소진행다인소logistic비조건회귀분석。결과170례초진T2DM환자DPN적환병솔위64．7％。 DPN조년령、RBG、UACR、HbA1 c고우무DPN조（ P＜0．05）。다인소logistic비조건회귀분석현시，년령、UACR、HbA1c위초진T2DM환자발생병발DPN적위험인소（P＜0．05）。결론초진T2DM환자역병발DPN，년령、HbA1c、UACR위초진T2DM환자발생DPN적위험인소。
Objective To investigate the risk factors for diabetic peripheral neuropathy ( DPN) in patients newly diagnosed as type 2 diabetes mellitus(T2DM).Methods According to the subjective symptoms and the abnormality of nerve conduction velocity (NCV), 170 patients newly diagnosed as T2DM were divided into non-DPN group(n=60) and DPN group(n=110).Body mass index(BMI), blood pressure,random blood glucose(RBG) when admission,fasting C-peptide(FCP),postprandial 2-hour C-peptide(2hCP),glycosylated hemoglobin ( HbA1 c ) , total cholesterol ( TC ) , triglyceride ( TG ) , low density lipoprotein cholesterol ( LDL-C ) , high density lipoprotein cholesterol(HDL-C),uric acid(UA),the ratio of urinary albumin and creatinine (UACR) were enrolled in univariant analysis.And the factors with statistical significance were enrolled in multivariate unconditional logistic regression analysis .Results The morbidity of DPN in 170 patients newly diagnosed as T2DM was 64.7%.Age,RBG,UACR,HbA1c of DPN group were higher than those of non-DNP group (P<0.05).Multivariate unconditional logistic regression analysis showed that age,UACR and HbA1c were the risk factors for DPN in patients newly diagnosed as T2DM (P<0.05).Conclusion Patients newly diagnosed as T2DM are liable to complicated with DPN.Age, HbA1 c and UACR are the risk factors for the onset of DPN in patients newly diagnosed as T 2DM.
