CAJ | 학술논문

目的：观察培美曲塞与多西他赛联合顺铂治疗晚期肺腺癌的临床效果。方法研究对象取自于我院2013年10月～2014年10月收治的66例晚期肺腺癌患者，按随机数字表法分为对照组（33例）与观察组（33例）。对照组采用多西他赛联合顺铂治疗；观察组采用培美曲塞联合顺铂治疗。记录两组患者治疗期间不良反应发生情况，随访8月，观察两组治疗效果。结果对照组与观察组治疗总有效率分别为45.5%和51.5%，两组比较差异无统计学意义（P＞0.05）；较对照组72.7%，观察组不良反应发生率48.5%低，两组比较差异有统计学意义（P＜0.05）。结论培美曲塞与多西他赛联合顺铂治疗晚期肺腺癌均能取得一定效果，前者治疗不良反应少，更具优势。
목적：관찰배미곡새여다서타새연합순박치료만기폐선암적림상효과。방법연구대상취자우아원2013년10월～2014년10월수치적66례만기폐선암환자，안수궤수자표법분위대조조（33례）여관찰조（33례）。대조조채용다서타새연합순박치료；관찰조채용배미곡새연합순박치료。기록량조환자치료기간불량반응발생정황，수방8월，관찰량조치료효과。결과대조조여관찰조치료총유효솔분별위45.5%화51.5%，량조비교차이무통계학의의（P＞0.05）；교대조조72.7%，관찰조불량반응발생솔48.5%저，량조비교차이유통계학의의（P＜0.05）。결론배미곡새여다서타새연합순박치료만기폐선암균능취득일정효과，전자치료불량반응소，경구우세。
Objective To observe the efficacy of pemetrexed and docetaxel combined cisplatin in the treatment of advanced lung adenocarcinoma.Methods Research object derived from October 2013 to October 2014,66 cases of patients with advanced lung adenocarcinoma,according to random number table method,was divided into control group(33 cases)and observation group(33 cases),control group adopted docetaxel with cisplatin therapy, observation group was treated with pemetrexed combined cisplatin,recorded of two groups of patients during treatment and the adverse reaction folowed up for 8 months,two groups of treatment effect were observed.Results The control group and observation group total effective rate were 45.5% and 51.5% respectively,were similar between the two groups had no statistical significance(P>0.05). Incidence of adverse reactions in observation group(72.7%)were lower than the control group(48.5%),comparing the two groups was statisticaly significant difference(P<0.05). ConclusionPemetrexed and docetaxel combined cisplatin treatment of advanced lung adenocarcinoma must effect can be obtained,less adverse reaction,the former treatment is much more advantages and is suitable for clinical promotion.