CAJ | 학술논문

目的：观察恶性脑胶质瘤术后三维适形放疗联合三苯氧胺治疗的疗效及不良反应。方法：60例恶性脑胶质瘤术后患者随机分为三维适形放疗联合三苯氧胺（治疗组）和三维适形放疗联合替莫唑胺（对照组）各30例。放疗采用6MV X 线三维适形放射治疗，2．0Gy／次，1次／d，5次／周，DT 56～60Gy。治疗组与对照组分别于放疗第一天开始口服三苯氧胺60mg／m2每日3次或替莫唑胺75mg／m2每日1次，至放疗结束。结果：治疗组与对照组1、2、3年生存率分别为63．3％、30．0％、23．0％和70．0％、33．3％、26．7％（χ2＝0．01、0．23、0．09，P ＞0．05），无统计学差异。三苯氧胺主要不良反应为血栓栓塞，发生率为6．7％。结论：三维适形放疗联合三苯氧胺术后患者生存率较好，且价格便宜，并未增加不良反应，适合临床推广应用。
목적：관찰악성뇌효질류술후삼유괄형방료연합삼분양알치료적료효급불량반응。방법：60례악성뇌효질류술후환자수궤분위삼유괄형방료연합삼분양알（치료조）화삼유괄형방료연합체막서알（대조조）각30례。방료채용6MV X 선삼유괄형방사치료，2．0Gy／차，1차／d，5차／주，DT 56～60Gy。치료조여대조조분별우방료제일천개시구복삼분양알60mg／m2매일3차혹체막서알75mg／m2매일1차，지방료결속。결과：치료조여대조조1、2、3년생존솔분별위63．3％、30．0％、23．0％화70．0％、33．3％、26．7％（χ2＝0．01、0．23、0．09，P ＞0．05），무통계학차이。삼분양알주요불량반응위혈전전새，발생솔위6．7％。결론：삼유괄형방료연합삼분양알술후환자생존솔교호，차개격편의，병미증가불량반응，괄합림상추엄응용。
Objective:To evaluate the efficacy and adverse effects of three dimensional conformal radiotherapy (3DCRT)with tamoxifen for postoperative malignant glioma.Methods:Sixty patients with postoperative malignant gli-oma were randomized into two groups,thirty patients received 3DCRT plus tamoxifen(treatment group),30 received 3DCRT plus temozolomide(control group).All patients were given 6MV X -ray,2.0Gy per fraction,once daily.The total dose varied up to DT 56 ~60Gy.For treatment group regimen was tamoxifen:60mg/(m2 ·d),control group was temozolomide:75mg/(m2 ·d),concomitantly with radiotherapy.Results:The 1 -,2 -,3 -year survival rates were 63.3%,30.0%,23.0% in treatment group,70.0%,33.3%,26.7% in control group(P >0.05).The thromboem-bolic rate in tamoxifen group was 6.7%.Conclusion:The treatment of 3DCRT plus tamoxifen results in a good sur-vival rate relatively,with lower -cost and no increased toxicity,is suitable for clinical popularization and application.