CAJ | 학술논문

目的：比较手术、放疗和光动力治疗分别联合小剂量化疗治疗早期声门型喉癌的临床疗效。方法：回顾性分析本院收治的122例早期声门型喉癌患者的临床资料，按照治疗方法分为手术组（83例）、放疗组（20例）和光动力组（19例），均联合小剂量化疗。观察三组的3、5年总生存率、2年无瘤生存率和2年局部控制率，并进行比较。结果：8例患者失访，定为死亡或复发。三组患者3、5年总生存率、2年无瘤生存率和2年局部控制率经比较差异均无统计学意义（均 P ＞0．05）。3组中一共有6例患者死于喉癌，1例患者死于第二原发恶性肿瘤，1例死于其他疾病。手术组13例出现并发症，放疗组7例出现并发症，光动力组2例出现并发症。入组患者中一共有27例出现复发转移，其中4例为颈部淋巴结转移，23例为原发灶复发。手术组、放疗组和光动力组分别有15例、3例和5例出现复发，三组复发率比较差异无统计学意义（P ＞0．05）。结论：手术、放疗和光动力治疗联合小剂量化疗治疗早期声门型喉癌可获得相似的临床疗效。
목적：비교수술、방료화광동력치료분별연합소제양화료치료조기성문형후암적림상료효。방법：회고성분석본원수치적122례조기성문형후암환자적림상자료，안조치료방법분위수술조（83례）、방료조（20례）화광동력조（19례），균연합소제양화료。관찰삼조적3、5년총생존솔、2년무류생존솔화2년국부공제솔，병진행비교。결과：8례환자실방，정위사망혹복발。삼조환자3、5년총생존솔、2년무류생존솔화2년국부공제솔경비교차이균무통계학의의（균 P ＞0．05）。3조중일공유6례환자사우후암，1례환자사우제이원발악성종류，1례사우기타질병。수술조13례출현병발증，방료조7례출현병발증，광동력조2례출현병발증。입조환자중일공유27례출현복발전이，기중4례위경부림파결전이，23례위원발조복발。수술조、방료조화광동력조분별유15례、3례화5례출현복발，삼조복발솔비교차이무통계학의의（P ＞0．05）。결론：수술、방료화광동력치료연합소제양화료치료조기성문형후암가획득상사적림상료효。
Objective:To explore the curative effect of operation,radiotherapy and photodynamic therapy in combi-nation with small dose of chemotherapy in the treatment of early glottic cancer.Methods:A retrospective analysis was performed on clinical data of 122 patients with early glottic cancer,and were divided into operation group(83 cases), radiotherapy group(20 cases),photodynamic therapy group(19 cases)according to treatment methods,were given joint of small dose chemotherapy.3,5 years survival rate and 2 years tumor free survival rate and local control rate at 2 years of the three groups were observed and compared.Results:Eight patients were lost to follow up,destined for death or recurrence.In 3 groups total of 6 patients died of laryngeal carcinoma,1 patient died in second primary malig-nant tumor,1 patient died of other diseases.Three patients of the 3 groups,the 5 years survival rate and 2 years tumor free survival rate and local control rate after 2 years were not significantly different(P >0.05).Complications oc-curred in 13 cases in operation group,2 cases occurred complications of photodynamic therapy group,radiotherapy group 7 cases with complications.A total of 27 cases developed recurrence and metastasis,including 4 cases of cervi-cal lymph node metastasis,23 cases of recurrence in primary lesion.Photodynamic therapy group and radiotherapy group,operation group were 5 cases,3 cases,15 cases relapsed.Conclusion:It have similar clinical efficacy of surger-y,radiotherapy and photodynamic therapy combined with low -dose chemotherapy in the treatment of early glottic car-cinoma.