CAJ | 학술논문

Objective:To estimate the antidepressant, anxiolytic and antinociceptive activities of ethanol extract ofSteudnera colocasiifolia K. Koch (S. colocasiifolia) leaves. <br> Methods: Swiss albino mice treated with 1% Tween solution, standard drugs and ethanol extract ofS. colocasiifolia,respectively, were subjected to the neurological and antinociceptive investigations. The tail suspension test and forced swimming test were used for testing antidepressant activity, where the parameter is the measurement of immobility time. Anxiolytic activity was evaluated by hole board model. Anti-nociceptive potential of the extract was also screened for centrally acting analgesic activity by using formalin induced licking response model and acetic acid induced writhing test was used for testing peripheral analgesic action. <br> Results: Ethanol extract ofS. colocasiifolia significantly decreased the period of immobility in both tested models (tail suspension and forced swimming models) of antidepressant activity. In the hole board model, there was a dose dependant (at 100 and 200 mg/kg) and a significant increase in the number of head dipping by comparing with control (1% Tween solution) (P <0.05 andP <0.001). In formalin induced licking model, a significant inhibition of pain compared to standard diclofenac sodium was observed (P <0.05 andP <0.001). In acetic acid induced test, there was a significant reduction of writhing response and pain in mice treated with leaves extract ofS. colocasiifoliaat 200 mg/kg body weight (P <0.05 andP <0.001). <br> Conclusions: The results proofed the prospective antidepressant, anxiolytic and antinociceptive activities of ethanol extract ofS. colocasiifolia leaves.