CAJ | 학술논문

目的：探讨胃肠道间质瘤(gastrointestinal stromal tumor，GISt)的临床病理特征，分析其预后相关影响因素。方法选取2010年1月至2013年6月我院50例手术确诊GISt患者，对其临床病理资料进行回顾性分析，并探讨影响GISt患者预后的相关因素。结果50例GISt患者包括消化道出血20例（40.0%）、腹痛或腹胀15例（30.0%）、体检发现6例（12.0%）、自觉腹部包块3例（6.0%）以及其他6例（12.0%）；CD117蛋白阳性率94.0%、CD34蛋白阳性率80.0%以及S-100蛋白阳性率14.0%。多因素Cox回归分析显示：肿瘤大小、危险度分级和手术方式是GISt患者术后生存率的影响因素（P＜0.05）。肿瘤直径越大、危险度升级、行不完全切除手术的GISt患者，预后较差。结论临床病理、手术因素与患者预后生存率密切相关，应正确认识GISt患者的临床病理特征，准确评估其预后，有针对性地改善影响患者预后的危险因素。
목적：탐토위장도간질류(gastrointestinal stromal tumor，GISt)적림상병리특정，분석기예후상관영향인소。방법선취2010년1월지2013년6월아원50례수술학진GISt환자，대기림상병리자료진행회고성분석，병탐토영향GISt환자예후적상관인소。결과50례GISt환자포괄소화도출혈20례（40.0%）、복통혹복창15례（30.0%）、체검발현6례（12.0%）、자각복부포괴3례（6.0%）이급기타6례（12.0%）；CD117단백양성솔94.0%、CD34단백양성솔80.0%이급S-100단백양성솔14.0%。다인소Cox회귀분석현시：종류대소、위험도분급화수술방식시GISt환자술후생존솔적영향인소（P＜0.05）。종류직경월대、위험도승급、행불완전절제수술적GISt환자，예후교차。결론림상병리、수술인소여환자예후생존솔밀절상관，응정학인식GISt환자적림상병리특정，준학평고기예후，유침대성지개선영향환자예후적위험인소。
Objective to investigate clinical pathological characteristics of gastrointestinal stromal tumor (GISt) and analyze its prognostic related factors. Methods choose 50 caese patients with GISt diagnosed by operation from January 2010 to June 2013, review and analyze their pathological data, and discuss related prognostic effected factors of GISt patients. Results among 50 patients with GISt, 20 patients were suffered with digestive tract bleeding (40.0%), abdominal pain or distension (30.0%), 6 cases discovered by physical examination (12.0%), 3 cases discovered by self with abdominal mass (6.0%), and others 6 cases (12.0%). CD117 protein positive rate is 94.0%, CD34 protein positive rate is 80.0%, and S-100 protein positive rate 14.0%. Multiple factors Cox regression analysis shows that tumor size, risk grade and surgical operation methods are inlfuencing factors for postoperative survival rate of GIST patients(P<0.05). And the greater diameter of tumor, higher grade of risk, and incomplete resection of GIST patients, prognosis is worse. Conclusion clinical pathology, surgical factors is closely related with prognosis survival rate of patients, and we should correctly understood clinical pathological characteristics of GIST patients, and accurately assess their prognosis, and improve risk factors for prognosis of patients with pointed references.