中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
42期
6826-6831
,共6页
组织构建%组织工程%胰岛素样生长因子%牙周组织%改建%牙周膜成纤维细胞%成骨细胞%破骨细胞%碱性磷酸酶
組織構建%組織工程%胰島素樣生長因子%牙週組織%改建%牙週膜成纖維細胞%成骨細胞%破骨細胞%堿性燐痠酶
조직구건%조직공정%이도소양생장인자%아주조직%개건%아주막성섬유세포%성골세포%파골세포%감성린산매
背景：正畸牙牙周组织改建主要是牙槽骨的改建。胰岛素样生长因子是牙周组织改建的重要因子，它在细胞的增殖、分化及个体的生长发育中发挥着重要的促进作用。目的：综述胰岛素样生长因子在牙周组织改建中的作用。方法：运用计算机检索 PubMed，中国知网以及贵州省数字图书馆等数据库，查阅至今有关胰岛素样生长因子在牙周组织改建中作用的中英文文献。关键词“胰岛素样生长因子；牙周组织；改建；insulin-like growth factor；Periodontal tissue；remodeling”。纳入胰岛素样生长因子与牙周组织改建中作用相关的文献进行归纳分析。结果与结论：胰岛素样生长因子属于胰岛素家族的一类多肽，对牙周膜中的成骨细胞、成纤维细胞以及诱导间充质细胞等，有促进其细胞迁移、增殖、分化、胶原和基质合成、增强碱性磷酸酶活性及在损伤修复中发挥着重要作用。在正畸治疗中，使用适宜矫治力的同时可适当运用能促进牙周组织改建的胰岛素样生长因子，加快正畸牙齿的移动，缩短患者的矫治时间。
揹景：正畸牙牙週組織改建主要是牙槽骨的改建。胰島素樣生長因子是牙週組織改建的重要因子，它在細胞的增殖、分化及箇體的生長髮育中髮揮著重要的促進作用。目的：綜述胰島素樣生長因子在牙週組織改建中的作用。方法：運用計算機檢索 PubMed，中國知網以及貴州省數字圖書館等數據庫，查閱至今有關胰島素樣生長因子在牙週組織改建中作用的中英文文獻。關鍵詞“胰島素樣生長因子；牙週組織；改建；insulin-like growth factor；Periodontal tissue；remodeling”。納入胰島素樣生長因子與牙週組織改建中作用相關的文獻進行歸納分析。結果與結論：胰島素樣生長因子屬于胰島素傢族的一類多肽，對牙週膜中的成骨細胞、成纖維細胞以及誘導間充質細胞等，有促進其細胞遷移、增殖、分化、膠原和基質閤成、增彊堿性燐痠酶活性及在損傷脩複中髮揮著重要作用。在正畸治療中，使用適宜矯治力的同時可適噹運用能促進牙週組織改建的胰島素樣生長因子，加快正畸牙齒的移動，縮短患者的矯治時間。
배경：정기아아주조직개건주요시아조골적개건。이도소양생장인자시아주조직개건적중요인자，타재세포적증식、분화급개체적생장발육중발휘착중요적촉진작용。목적：종술이도소양생장인자재아주조직개건중적작용。방법：운용계산궤검색 PubMed，중국지망이급귀주성수자도서관등수거고，사열지금유관이도소양생장인자재아주조직개건중작용적중영문문헌。관건사“이도소양생장인자；아주조직；개건；insulin-like growth factor；Periodontal tissue；remodeling”。납입이도소양생장인자여아주조직개건중작용상관적문헌진행귀납분석。결과여결론：이도소양생장인자속우이도소가족적일류다태，대아주막중적성골세포、성섬유세포이급유도간충질세포등，유촉진기세포천이、증식、분화、효원화기질합성、증강감성린산매활성급재손상수복중발휘착중요작용。재정기치료중，사용괄의교치력적동시가괄당운용능촉진아주조직개건적이도소양생장인자，가쾌정기아치적이동，축단환자적교치시간。
BACKGROUND:Orthodontic treatment is a mechanical force for tooth to cause the remodeling of periodontal tissue, produced by the tooth movement. The main aspect of orthodontic periodontal tissue remodeling is the alveolar bone. Insulin-like growth factor is an important factor in the remodeling of periodontal tissue, which plays an important role in the growth, differentiation and growth of the cels. OBJECTIVE:To review the role of insulin-like growth factors in periodontal tissue remodeling. METHODS: A computer-based retrieval of PubMed, CNKI and Guizhou Province Digital Library Database was performed to search articles related to the role of insulin-like growth factors in periodontal tissue remodeling. The keywords were “insulin-like growth factor; periodontal tissue; remodeling” in English and Chinese, respectively. RESULTS AND CONCLUSION: Insulin like growth factor belongs to the insulin family, a kind of peptides, which can promote the migration, proliferation, differentiation, colagen and matrix synthesis and alkaline phosphatase activity of osteoblasts, fibroblasts and mesenchymal cels in the periodontal ligament. It also plays an important role in the repair of injury. During orthodontic treatment, the use of suitable orthodontic force combined with insulin-like growth factor can promote periodontal tissue remodeling, accelerate the orthodontic tooth movement and shorten the treatment time for patients.
