中国卒中杂志
中國卒中雜誌
중국졸중잡지
Chinese Journal of Stroke
2015年
11期
941-946
,共6页
刘广志%曹江慧%梅斌%刘煜敏
劉廣誌%曹江慧%梅斌%劉煜敏
류엄지%조강혜%매빈%류욱민
分支动脉粥样硬化病%腔隙性脑梗死%临床特征%meta分析
分支動脈粥樣硬化病%腔隙性腦梗死%臨床特徵%meta分析
분지동맥죽양경화병%강극성뇌경사%림상특정%meta분석
Branch atheromatous disease%Lacunar infarction%Clinical characteristics%Meta analysis
目的比较分支动脉粥样硬化病(branch atheromatous disease,BAD)和腔隙性脑梗死(lacunar infarction,LI)之间的临床差异。<br> 方法检索国内外数据库,查找分支动脉粥样硬化病和腔隙性脑梗死相关文献,使用RevMan 5.2进行数据处理,对文献进行meta分析。<br> 结果在中国人群中BAD患者年龄小于LI患者(MD -2.70,95%CI -4.29~-1.11,P<0.01);在日本人群中BAD患者年龄大于LI患者(MD 2.58,95%CI 0.75~4.41,P<0.01)。BAD患者的高脂血症患病率更高(OR 1.26,95%CI 1.03~1.55,P=0.03)。行敏感性分析后发现,BAD患者糖尿病(OR 1.28,<br> 95%CI 1.02~1.61,P=0.03)、入院时美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分(MD 0.76,95%CI 0.50~1.02,P<0.01)和预后情况(OR 0.54,95%CI 0.38~0.77, P<0.01)在BAD和LI患者之间存在差异性显著。<br> 结论 BAD患者糖尿病、高脂血症发病率显著高于LI患者,其早期神经功能和预后情况均差于LI患者。中国人群中BAD和LI患者的年龄分布特征与和日本人群相反。
目的比較分支動脈粥樣硬化病(branch atheromatous disease,BAD)和腔隙性腦梗死(lacunar infarction,LI)之間的臨床差異。<br> 方法檢索國內外數據庫,查找分支動脈粥樣硬化病和腔隙性腦梗死相關文獻,使用RevMan 5.2進行數據處理,對文獻進行meta分析。<br> 結果在中國人群中BAD患者年齡小于LI患者(MD -2.70,95%CI -4.29~-1.11,P<0.01);在日本人群中BAD患者年齡大于LI患者(MD 2.58,95%CI 0.75~4.41,P<0.01)。BAD患者的高脂血癥患病率更高(OR 1.26,95%CI 1.03~1.55,P=0.03)。行敏感性分析後髮現,BAD患者糖尿病(OR 1.28,<br> 95%CI 1.02~1.61,P=0.03)、入院時美國國立衛生研究院卒中量錶(national institutes of health stroke scale,NIHSS)評分(MD 0.76,95%CI 0.50~1.02,P<0.01)和預後情況(OR 0.54,95%CI 0.38~0.77, P<0.01)在BAD和LI患者之間存在差異性顯著。<br> 結論 BAD患者糖尿病、高脂血癥髮病率顯著高于LI患者,其早期神經功能和預後情況均差于LI患者。中國人群中BAD和LI患者的年齡分佈特徵與和日本人群相反。
목적비교분지동맥죽양경화병(branch atheromatous disease,BAD)화강극성뇌경사(lacunar infarction,LI)지간적림상차이。<br> 방법검색국내외수거고,사조분지동맥죽양경화병화강극성뇌경사상관문헌,사용RevMan 5.2진행수거처리,대문헌진행meta분석。<br> 결과재중국인군중BAD환자년령소우LI환자(MD -2.70,95%CI -4.29~-1.11,P<0.01);재일본인군중BAD환자년령대우LI환자(MD 2.58,95%CI 0.75~4.41,P<0.01)。BAD환자적고지혈증환병솔경고(OR 1.26,95%CI 1.03~1.55,P=0.03)。행민감성분석후발현,BAD환자당뇨병(OR 1.28,<br> 95%CI 1.02~1.61,P=0.03)、입원시미국국립위생연구원졸중량표(national institutes of health stroke scale,NIHSS)평분(MD 0.76,95%CI 0.50~1.02,P<0.01)화예후정황(OR 0.54,95%CI 0.38~0.77, P<0.01)재BAD화LI환자지간존재차이성현저。<br> 결론 BAD환자당뇨병、고지혈증발병솔현저고우LI환자,기조기신경공능화예후정황균차우LI환자。중국인군중BAD화LI환자적년령분포특정여화일본인군상반。
Objective To make a further comparison for the clinical differences between branch atheromatous disease(BAD) and lacunar infarction(LI). <br> Methods We searched the Chinese and foreign language databases for relevant studies. Statistical analysis were performed by RevMan 5.2 software. <br> Results In China, BAD patients were younger than LI patients(MD-2.70, 95%CI-4.29~-1.11, P<0.01); In Japan, BAD patients were older than LI patients(MD 2.58, 95%CI 0.75~4.41,P<0.01). Hyperlipidaemia affected more BAD patients(OR 1.26, 95%CI 1.03~1.55,P=0.03). After the sensitivity analysis, diabetes mellitus(OR 1.28, 95%CI 1.02~1.61,P=0.03), initial national institutes of health stroke scale(NIHSS score)(MD 0.76, 95%CI 0.50~1.02,P<0.01) and prognosis (OR 0.54, 95%CI 0.38~0.77,P<0.01) showed signiifcant differences between BAD and LI. <br> Conclusion Hyperlipidaemia and diabetes mellitus affected more BAD patients, compared to LI patients. The nerve functional and prognosis of BAD patients were worse than LI patients. The characteristic of age distribution in Chinese BAD and LI patients was contrary to Japanese.