CAJ | 학술논문

目的：探讨链球菌肺炎( SP)儿童患者发生耐药菌感染的危险因素以及常见药物耐药情况。方法选取我院儿科病房48例儿童链球菌肺炎患者，对临床分离的48株肺炎链球菌进行药敏试验，针对常见抗菌药物耐药情况以及发生耐药性的危险因素进行分析。结果肺炎链球菌对红霉素、阿奇霉素的耐药率分别为93．75%和91．67%，对氨苄西林、头孢呋辛、头孢曲松敏感率分別为77．1%、83．33%、87．5%。单因素分析显示，年龄、使用疫苗以及就诊前应用抗生素等因素存在统计学差异(P﹤0．05)，是儿童链球菌肺炎发生耐药菌感染的危险因素。并表现出多重耐药，尤其对青霉素和红霉素耐药的菌株。结论本医院所在儿科病房患儿链球菌肺炎耐药形势严峻，对多种抗生素呈广泛的不同程度的耐药，引起耐药的危险因素较多，应动态监测肺炎链球菌的耐药情况，合理选择抗生素，提高疗效。
목적：탐토련구균폐염( SP)인동환자발생내약균감염적위험인소이급상견약물내약정황。방법선취아원인과병방48례인동련구균폐염환자，대림상분리적48주폐염련구균진행약민시험，침대상견항균약물내약정황이급발생내약성적위험인소진행분석。결과폐염련구균대홍매소、아기매소적내약솔분별위93．75%화91．67%，대안변서림、두포부신、두포곡송민감솔분별위77．1%、83．33%、87．5%。단인소분석현시，년령、사용역묘이급취진전응용항생소등인소존재통계학차이(P﹤0．05)，시인동련구균폐염발생내약균감염적위험인소。병표현출다중내약，우기대청매소화홍매소내약적균주。결론본의원소재인과병방환인련구균폐염내약형세엄준，대다충항생소정엄범적불동정도적내약，인기내약적위험인소교다，응동태감측폐염련구균적내약정황，합리선택항생소，제고료효。
Objective To explore the risk factors of drug resistance in 48 children with streptococcus pneu-monia. Methods 48 strains of streptococcus pneumonia were given drug sensitivity test. According to common anti-microbial resistance, the risk factors of drug resistance were analyzed. Results The drug resistance of streptococcus pneumonia to erythromycin and azithromycin was respectively 93. 75% and 91. 67%. The sensitivity to ampicillin, cefuroxime and ceftriaxone was 77. 1%, 83. 33% and 87. 5% respectively. Single factor analysis showed there were significant differences in age, the use of vaccines and antibiotics use before hospital (P<0. 05). It showed multiple drug resistance, especially to penicillin and erythromycin. Conclusion The drug resistance of streptococcus pneu-monia in the department of paediatrics is serious, showing a certain resistance to many antibiotics. There are many reasons causing the drug resistance, which should be given dynamic monitoring. And the antibiotics should be chosen according to the sensitivity test.