临床肺科杂志
臨床肺科雜誌
림상폐과잡지
Journal of Clinical Pulmonary Medicine
2015年
12期
2214-2216
,共3页
人副流感病毒3型%呼吸道合胞病毒%临床特征%儿童
人副流感病毒3型%呼吸道閤胞病毒%臨床特徵%兒童
인부류감병독3형%호흡도합포병독%림상특정%인동
human parainfluenza virus type 3%respiratory syncytial virus%clinical feature%children
目的：探讨苏州地区因急性呼吸道感染住院患儿中副流感病毒3型( HPIV3)感染临床特征。方法收集2013年1月~2013年12月因急性呼吸道感染住院2298例患儿的痰标本,应用直接免疫荧光法测呼吸道合胞病毒、流感病毒(A、B)、人副流感病毒(1~3)和腺病毒,采用实时PCR检测人博卡病毒DNA,逆转录PCR检测人偏肺病毒及鼻病毒RNA。分析人副流感病毒3型感染患儿的临床特点及流行病学特征,并与呼吸道合胞病毒(RSV)感染进行比较。结果2298例痰标本中病毒检测阳性者983例(42.78%),HPIV 3阳性98例(4.26%),次于RSV阳性233例(10.14%)；HPIV3常年均可感染,以春、夏季为发病高峰,夏季发病率高达45.92%；发病年龄均为6岁以下儿童,1岁以下检出率高,占62.30%；98例阳性标本中,HPIV3单独感染61例,主要引起支气管肺炎(80.33%)、急性毛细支气管炎(13.11%),以咳嗽(96.72%)、喘息(44.26%)、发热(47.54%)为主要临床症状；与RSV比较,HPIV3住院患儿喘息发生率低,主要引起支气管肺炎,差异有统计学意义(P<0.05)。结论 HPIV3是苏州地区住院患儿呼吸道感染的重要病原之一,其有单独的致病性,与RSV相比,在季节分布、临床表现等方面有一定差异。
目的：探討囌州地區因急性呼吸道感染住院患兒中副流感病毒3型( HPIV3)感染臨床特徵。方法收集2013年1月~2013年12月因急性呼吸道感染住院2298例患兒的痰標本,應用直接免疫熒光法測呼吸道閤胞病毒、流感病毒(A、B)、人副流感病毒(1~3)和腺病毒,採用實時PCR檢測人博卡病毒DNA,逆轉錄PCR檢測人偏肺病毒及鼻病毒RNA。分析人副流感病毒3型感染患兒的臨床特點及流行病學特徵,併與呼吸道閤胞病毒(RSV)感染進行比較。結果2298例痰標本中病毒檢測暘性者983例(42.78%),HPIV 3暘性98例(4.26%),次于RSV暘性233例(10.14%)；HPIV3常年均可感染,以春、夏季為髮病高峰,夏季髮病率高達45.92%；髮病年齡均為6歲以下兒童,1歲以下檢齣率高,佔62.30%；98例暘性標本中,HPIV3單獨感染61例,主要引起支氣管肺炎(80.33%)、急性毛細支氣管炎(13.11%),以咳嗽(96.72%)、喘息(44.26%)、髮熱(47.54%)為主要臨床癥狀；與RSV比較,HPIV3住院患兒喘息髮生率低,主要引起支氣管肺炎,差異有統計學意義(P<0.05)。結論 HPIV3是囌州地區住院患兒呼吸道感染的重要病原之一,其有單獨的緻病性,與RSV相比,在季節分佈、臨床錶現等方麵有一定差異。
목적：탐토소주지구인급성호흡도감염주원환인중부류감병독3형( HPIV3)감염림상특정。방법수집2013년1월~2013년12월인급성호흡도감염주원2298례환인적담표본,응용직접면역형광법측호흡도합포병독、류감병독(A、B)、인부류감병독(1~3)화선병독,채용실시PCR검측인박잡병독DNA,역전록PCR검측인편폐병독급비병독RNA。분석인부류감병독3형감염환인적림상특점급류행병학특정,병여호흡도합포병독(RSV)감염진행비교。결과2298례담표본중병독검측양성자983례(42.78%),HPIV 3양성98례(4.26%),차우RSV양성233례(10.14%)；HPIV3상년균가감염,이춘、하계위발병고봉,하계발병솔고체45.92%；발병년령균위6세이하인동,1세이하검출솔고,점62.30%；98례양성표본중,HPIV3단독감염61례,주요인기지기관폐염(80.33%)、급성모세지기관염(13.11%),이해수(96.72%)、천식(44.26%)、발열(47.54%)위주요림상증상；여RSV비교,HPIV3주원환인천식발생솔저,주요인기지기관폐염,차이유통계학의의(P<0.05)。결론 HPIV3시소주지구주원환인호흡도감염적중요병원지일,기유단독적치병성,여RSV상비,재계절분포、림상표현등방면유일정차이。
Objective To investigate the clinical features of human parainfluenza virus type 3 ( HPIV3 ) in-fection in Suzhou area. Methods From January 2013 to December 2013, the respiratory sputum was collected from 2298 patients with acute infections. Direct immunofluorescence was applied to test parainfluenza virus (1~3), influ-enza virus A and B, respiratory syncytial virus ( RSV) and adenovirus. DNA of HBoV was tested by real-time PCR, and RNA of human metapneumovirus and human rhinovirus was tested by reverse-transcription. The epidemiology and clinical features of patients with HPIV3 infection were analyzed and compared with those RSV infection. Results The positive rate of virus was 42. 78% (983 cases), the positive rate of HPIV3 was 4. 26% (98 cases), and 10. 14% of postive ferior RSV (233 cases). HPIV3 infection could occur all the year around but most seen in spring and summer, with the highest incidence of 45. 92% in summer. The highest detection rate (60. 20%) occurred in pa-tients aged from 1 to 12 months, almost younger than 6 years old. 61 cases were the only pathogen of HPIV3. Cough (96. 72%), wheezing (44. 26%) and fever (47. 54%) were more common in patients with HPIV3. The percentage of bronchopneumonia caused by HPIV3 infection was 80. 33%. Compared with RSV infection, HPIV3 had a less in-cidence of wheezing (P<0. 05). Conclusion HPIV3 is one of the most importment viral pathogens in children with respiratory infection in Suzhou area. Infection can be caused by HPIV3 only. The occurrences of season and clinical feature of HPIV3 infection are difference with RSV infection.
