CAJ | 학술논문

目的：评价中西医结合治疗干眼的有效性和安全性，分析临床研究的现状。方法：检索万方全文数据库、维普数据库、中国期刊网全文数据库( CNKI)、美国医学文摘数据库( PubMed)、中国生物医学文献数据库( CBM)中关于中西医结合治疗干眼的临床文献，纳入中西医结合治疗干眼与单纯西医药物治疗比较的随机对照试验(RCT)和临床对照试验( CCT)，按照循证医学系统评价的方法，逐一评价纳入研究的质量并根据 Jadad 评分量表对纳入文献进行评分，提取有效数据，采用RevMan5.2统计软件进行Meta分析。结果：9篇文献符合纳入标准，共计1092例患者。Meta分析显示中西医结合治疗干眼与单纯西医药物治疗总有效率比较，差异有统计意义( P＜0．05)。结论：中西医结合治疗干眼的总有效率优于单纯西医药物疗法，且无明显不良反应。但鉴于缺乏高质量的随机对照研究支持，且有文献发表偏倚的存在，尚需要更多设计良好的临床随机对照试验来进一步证实其效果。
목적：평개중서의결합치료간안적유효성화안전성，분석림상연구적현상。방법：검색만방전문수거고、유보수거고、중국기간망전문수거고( CNKI)、미국의학문적수거고( PubMed)、중국생물의학문헌수거고( CBM)중관우중서의결합치료간안적림상문헌，납입중서의결합치료간안여단순서의약물치료비교적수궤대조시험(RCT)화림상대조시험( CCT)，안조순증의학계통평개적방법，축일평개납입연구적질량병근거 Jadad 평분량표대납입문헌진행평분，제취유효수거，채용RevMan5.2통계연건진행Meta분석。결과：9편문헌부합납입표준，공계1092례환자。Meta분석현시중서의결합치료간안여단순서의약물치료총유효솔비교，차이유통계의의( P＜0．05)。결론：중서의결합치료간안적총유효솔우우단순서의약물요법，차무명현불량반응。단감우결핍고질량적수궤대조연구지지，차유문헌발표편의적존재，상수요경다설계량호적림상수궤대조시험래진일보증실기효과。
Objective:To assess the evidence of efficacy and safety of combining traditional Chinese and western medicine for dry eyes and analyze the current situation of its clinical setting.Methods:The clinical literatures about combination of Chinese traditional and Western medicine treatment for dry eyes in Wanfang,Chongqing Weipu Database for Chinese Technical Periodicals (VIP),China National Knowledge Infrastructure (CNKI),Pubmed and CBM clinical literature were searched systemically.Randomized controlled trials (RCT) and controlled clinical trials ( CCT) that compared the effect of combining traditional Chinese and western medicine for dry eyes with drug treatment were enrolled into the study. The methodological quality of included trials were assessed based on the modified Jadad scale.Valid data were facilitated by using RevMan 5.2.Results:9trials involving 1092 participants satisfied the minimum criteria for meta-analysis.The evidence showed that the overall effective rate of treatment within the group receiving combination of Chinese traditional and Western medicine treatment was higher than that in drug group,there were statistically significant differences (P<0.05).Conclusion:The overall effective rate of combining traditional Chinese and western medicine for dry eyes is significantly superior to drug treatment,and has no obvious adverse reactions.But given the lack of high quality randomized controlled research,and the existence of literature publication bias,it needs more well-designed,randomized controlled clinical trials to confirm the effect.