CAJ | 학술논문

节段型白癜风是白癜风的一种亚型,沿皮神经节段分布.与其他类型白癜风相比,其在临床表现、发病机制和治疗等方面均有其自身特点.临床上具有发病早、皮损不对称、进展迅速的特点,很少向其他部位蔓延,很少伴有其他自身免疫病.病因及发病机制尚不明确,目前有神经学说、遗传学说、免疫学说及三步骤理论等.节段型白癜风的一线治疗是避免诱发因素,局部外用糖皮质激素、钙调神经磷酸酶抑制剂、维生素D3衍生物等,快速进展期可考虑系统给予小剂量糖皮质激素;二线治疗为窄谱中波紫外线、准分子激光或氦氖激光等;三线治疗是复色仍不理想,考虑手术治疗.
절단형백전풍시백전풍적일충아형,연피신경절단분포.여기타류형백전풍상비,기재림상표현、발병궤제화치료등방면균유기자신특점.림상상구유발병조、피손불대칭、진전신속적특점,흔소향기타부위만연,흔소반유기타자신면역병.병인급발병궤제상불명학,목전유신경학설、유전학설、면역학설급삼보취이론등.절단형백전풍적일선치료시피면유발인소,국부외용당피질격소、개조신경린산매억제제、유생소D3연생물등,쾌속진전기가고필계통급여소제량당피질격소;이선치료위착보중파자외선、준분자격광혹양내격광등;삼선치료시복색잉불이상,고필수술치료.
Segmental vitiligo,a subtype of vitiligo,is distributed segmentally along cutaneous nerves.Compared with other types of vitiligo,segmental vitiligo has distinctive clinical manifestations,pathogenesis and treatment.It is characterized by early onset,asymmetric skin lesions,rapid progression,and low likelihood of spreading to other sites or being accompanied by other autoimmune diseases.The etiology and pathogenesis of segmental vitiligo remain unclear,and several hypotheses have been put forward,such as the neural theory,genetic theory,immunological theory and a new three-step theory.The first-line treatment of segmental vitiligo is avoidance of causative factors,topical application of glucocorticoids,calcineurin inhibitors,vitamin D3 derivatives,and oral administration of a small dose of glucocorticoids at rapid progression stage.The second-line treatment is narrow-band ultraviolet B,excimer laser or helium-neon laser,etc.Surgery may serve as the third-line treatment when repigmentation is unsatisfying.