CAJ | 학술논문

目的：探讨超声电导经皮透药治疗包裹性结核性胸膜炎的临床疗效。方法选择西安市结核病胸部肿瘤医院2011年1月至2015年1月期间经胸膜活检确诊的包裹性结核性胸膜炎患者190例,按照完全随机法分为单纯化疗组(95例),化疗联合超声透药组(95例),超声电导组在全身化疗的基础上加用超声电导经皮透药治疗,观察治疗1、2、6个月三个时间点两组患者的症状改善情况、胸水吸收情况、胸膜肥厚情况、并发症及不良反应。结果治疗组第1个月、2个月和6个月时胸水吸收率为35．8%、61．1%和94．7%,对照组分别为18．9%,29．5%,89．5%,两组60天内胸水吸收的人数相比有显著差异(P<0．05),另外,治疗6个月时治疗组轻度肥厚50．5%,中度肥厚37．9%,重度肥厚11．6%,对照组分别为31．6%,40．0%,28．4%,两组统计学有显著差异(P<0．05)。两组并发症及不良反应发生率差异无统计学意义。结论超声电导经皮透药治疗包裹性结核性胸膜炎可以加快胸水吸收,减少胸膜肥厚,且不良反应小、安全有效,是一种新型给药途径。
목적：탐토초성전도경피투약치료포과성결핵성흉막염적림상료효。방법선택서안시결핵병흉부종류의원2011년1월지2015년1월기간경흉막활검학진적포과성결핵성흉막염환자190례,안조완전수궤법분위단순화료조(95례),화료연합초성투약조(95례),초성전도조재전신화료적기출상가용초성전도경피투약치료,관찰치료1、2、6개월삼개시간점량조환자적증상개선정황、흉수흡수정황、흉막비후정황、병발증급불량반응。결과치료조제1개월、2개월화6개월시흉수흡수솔위35．8%、61．1%화94．7%,대조조분별위18．9%,29．5%,89．5%,량조60천내흉수흡수적인수상비유현저차이(P<0．05),령외,치료6개월시치료조경도비후50．5%,중도비후37．9%,중도비후11．6%,대조조분별위31．6%,40．0%,28．4%,량조통계학유현저차이(P<0．05)。량조병발증급불량반응발생솔차이무통계학의의。결론초성전도경피투약치료포과성결핵성흉막염가이가쾌흉수흡수,감소흉막비후,차불량반응소、안전유효,시일충신형급약도경。
Objective To discuss the curative effect of electrophonophoresis through skin in the treatment of tuberculous encysted pleurisy. Methods 190 tuberculous encysted pleurisy patients who were confirmed through pleural biopsy from January, 2011 to January, 2015 in Xi'an Thoracic Medicine Hospital were chosen. They were ran-domly divided into two group, the group A ( chemotherapy only, 95 cases) and the group B ( chemotherapy combined with phonophoresis treatment, 95 cases) . The group B was treated with electrophonophoresis through skin on the ba-sis of systemic chemotherapy. The improvement of symptoms, the absorption of pleural effusion, the situation of pachynsis pleurae, complications and adverse reactions were observed between the two groups 1, 2 and 6 months after the treatment. Results The absorption rate of pleural effusion were 35. 8%, 61. 1% and 94. 7% in the group B, and 18. 9%, 29. 5% and 89. 5% in the group A respectively 1, 2 and 6 months after the treatment. There was sig-nificant difference in pleural effusion absorption during 60 days (P<0. 05). In addition, the mild pachynsis in the group B was 50. 5%, moderate pachynsis was 37. 9%, and severe pachynsis was 11. 6%, 31. 6%, 40. 0% and 28. 4% respectively in the control group (P<0. 05). The occurrence of complications and adverse reactions had no statistical significance between the two groups. Conclusion Electrophonophoresis through skin is a new method of medicine delivery in the treatment of tuberculous encysted pleurisy, which can speed up the absorption of pleural effu-sion, reduce pachynsis pleurae and have little adverse reactions.