CAJ | 학술논문

目的：探讨肥胖相关的血清因子瘦素(LEP)、胰岛素生长因子-1(IGF-1)与阻塞性睡眠呼吸暂停低通气综合征( OSAHS)的关联性,为指导OSAHS临床诊治和预防提供科学依据。方法将华北理工大学附属医院呼吸科睡眠室和唐山协和医院耳鼻喉科睡眠室就诊并经过PSG(多导睡眠监测)确诊的131例重度OSAHS患者作为病例组；健康查体的90例非OSAHS者作为正常非肥胖组,其中45例BMI>=25的为正常肥胖组,另45例BMI<25的为正常非肥胖组。所有入选对象均使用统一调查表收集患者的一般情况、临床特征等资料填表登记；并对每位入选对象,清晨空腹采血捡测瘦素、胰岛素生长因子-1( IGF-1)。结果在本研究中,LEP水平在正常对照组最低,肥胖对照组次之,病例组最高,3组间差异无统计学意,LEP暴露水平与OSAHS的关联有统计学意义。 LEP水平升高,OSAHS危险性增高(χ2=6．45,OR 2．47)。而上述3个组间的IGF-1水平比较(P=0．00)。两两比较,各项指标均以病例组最低,肥胖组次之,正常对照组最高,组间差异均有统计学意义。(OR=6．94)。结论 LEP、IGF-1水平与OSAHS均有关联,LEP水平升高,OSAHS危险性增高,IGF-1暴露水平低的肥胖者,OSAHS的危险性升高。
목적：탐토비반상관적혈청인자수소(LEP)、이도소생장인자-1(IGF-1)여조새성수면호흡잠정저통기종합정( OSAHS)적관련성,위지도OSAHS림상진치화예방제공과학의거。방법장화북리공대학부속의원호흡과수면실화당산협화의원이비후과수면실취진병경과PSG(다도수면감측)학진적131례중도OSAHS환자작위병례조；건강사체적90례비OSAHS자작위정상비비반조,기중45례BMI>=25적위정상비반조,령45례BMI<25적위정상비비반조。소유입선대상균사용통일조사표수집환자적일반정황、림상특정등자료전표등기；병대매위입선대상,청신공복채혈검측수소、이도소생장인자-1( IGF-1)。결과재본연구중,LEP수평재정상대조조최저,비반대조조차지,병례조최고,3조간차이무통계학의,LEP폭로수평여OSAHS적관련유통계학의의。 LEP수평승고,OSAHS위험성증고(χ2=6．45,OR 2．47)。이상술3개조간적IGF-1수평비교(P=0．00)。량량비교,각항지표균이병례조최저,비반조차지,정상대조조최고,조간차이균유통계학의의。(OR=6．94)。결론 LEP、IGF-1수평여OSAHS균유관련,LEP수평승고,OSAHS위험성증고,IGF-1폭로수평저적비반자,OSAHS적위험성승고。
Objective To investigate the relationship of obstructive sleep apnea hypopnea syndrome ( OS-AHS) with leptin and insulin-like growth factor-1 (IGF-1). Methods The study selected 131 patients with severe OSAHS as the group A, 45 healthy controls without OSAHS as the group B and 45 obesity controls as the group C. All of them were diagnosed by PSG. The serum leptin and IGF-1 from everyone were measured. Results The level of leptin in the OSAHS group was the highest, it showed no significant difference among the 3 groups (P>0. 05). The level of LEP was correlated with OSAHS (P<0. 05). The high level of LEP increased the risk of OSAHS(χ2 =6. 45, OR=2. 47). The level of IGF-1 was the lowest in the OSAHS group, followed by the control group and the o-besity control group (P<0. 05). Conclusion The levels of leptin and IGF-1 are correlated with OSAHS, and the higher leptin and lower IGF-1 indicate OSAHS patients with high risk.