中国临床新医学
中國臨床新醫學
중국림상신의학
Chinese Journal of New Clinical Medicine
2015年
11期
1036-1038
,共3页
郭珊珊%范秀芳%王和香%王营营%吕洪
郭珊珊%範秀芳%王和香%王營營%呂洪
곽산산%범수방%왕화향%왕영영%려홍
大黄蛰虫胶囊%肝纤维化%基质金属蛋白酶-2%大鼠%明胶酶谱
大黃蟄蟲膠囊%肝纖維化%基質金屬蛋白酶-2%大鼠%明膠酶譜
대황칩충효낭%간섬유화%기질금속단백매-2%대서%명효매보
Dahuangzhechong capsule%Hepatic fibrosis%Matrix metalloproteinase-2( MMP-2)%Rat%Zymography
目的:探讨大鼠肝纤维化中大黄蛰虫胶囊对基质金属蛋白酶-2(MMP-2)活性的影响。方法采用明胶酶谱法检测肝组织MMP-2活性,采用天狼猩红染色法判断肝纤维化程度。结果随着肝纤维化程度的加重,大黄蛰虫胶囊组MMP-2活性升高幅度明显低于模型组( P<0.05),但高于空白组( P<0.05)。结论大黄蛰虫胶囊可能通过降低MMP-2活性抑制大鼠肝纤维化发展。
目的:探討大鼠肝纖維化中大黃蟄蟲膠囊對基質金屬蛋白酶-2(MMP-2)活性的影響。方法採用明膠酶譜法檢測肝組織MMP-2活性,採用天狼猩紅染色法判斷肝纖維化程度。結果隨著肝纖維化程度的加重,大黃蟄蟲膠囊組MMP-2活性升高幅度明顯低于模型組( P<0.05),但高于空白組( P<0.05)。結論大黃蟄蟲膠囊可能通過降低MMP-2活性抑製大鼠肝纖維化髮展。
목적:탐토대서간섬유화중대황칩충효낭대기질금속단백매-2(MMP-2)활성적영향。방법채용명효매보법검측간조직MMP-2활성,채용천랑성홍염색법판단간섬유화정도。결과수착간섬유화정도적가중,대황칩충효낭조MMP-2활성승고폭도명현저우모형조( P<0.05),단고우공백조( P<0.05)。결론대황칩충효낭가능통과강저MMP-2활성억제대서간섬유화발전。
Objective To investigate the effect of Dahuangzhechong capsule on matrix metalloproteinase-2 ( MMP-2) activity in rats with hepatic fibrosis.Methods The collagen deposition and MMP-2 activity in the liver tis-sues were detected by Sirius red staining and zymography respectively.Results With the severity of liver fibrosis, the rising of MMP-2 activity in Dahuangzhechong capsule group was significantly lower than that in the liver fibrosis model group(P<0.05), but greater than that in the control group(P<0.05).Conclusion Dahuangzhechong cap-sule has a depressant effect on MMP-2 activity and inhibits the development of hepatic fibrosis in rats.