四川医学
四川醫學
사천의학
Sichuan Medical Journal
2015年
11期
1583-1586
,共4页
钆塞酸二钠%肝细胞肝癌%Meta 分析
釓塞痠二鈉%肝細胞肝癌%Meta 分析
구새산이납%간세포간암%Meta 분석
gadoxetic acid disodium%hepatocellular carcinoma%Meta-analysis
目的：对钆塞酸二钠增强 MRI 在肝硬化背景下诊断原发型肝癌的文献进行荟萃分析,评价钆塞酸二钠增强 MRI 在肝硬化背景下诊断原发型肝癌的价值。方法检索数据库包括 MEDLINE, EMBASE, Cochrane Library databas-es,检索时间为2000年1月到2015年3月。提取相关数据,采用 Stata 12．0及 Meta-Disc 1．4软件进行 Meta 分析。结果最终纳入16篇参考文献,共计2474个病灶。 Meta 分析结果示,钆塞酸二钠增强 MRI 在肝硬化背景下诊断原发型肝癌的敏感性、特异性、曲线下面积分别为0．921(95% CI：0．887,0．946),0．909(95% CI：0．823,0．955)和0．96(95% CI：0．94,0．97)。结论钆塞酸二钠增强 MRI 诊断原发型肝癌具有较高的诊断效能,但仍需大样本设计良好的研究进一步证实其临床运用价值。
目的：對釓塞痠二鈉增彊 MRI 在肝硬化揹景下診斷原髮型肝癌的文獻進行薈萃分析,評價釓塞痠二鈉增彊 MRI 在肝硬化揹景下診斷原髮型肝癌的價值。方法檢索數據庫包括 MEDLINE, EMBASE, Cochrane Library databas-es,檢索時間為2000年1月到2015年3月。提取相關數據,採用 Stata 12．0及 Meta-Disc 1．4軟件進行 Meta 分析。結果最終納入16篇參攷文獻,共計2474箇病竈。 Meta 分析結果示,釓塞痠二鈉增彊 MRI 在肝硬化揹景下診斷原髮型肝癌的敏感性、特異性、麯線下麵積分彆為0．921(95% CI：0．887,0．946),0．909(95% CI：0．823,0．955)和0．96(95% CI：0．94,0．97)。結論釓塞痠二鈉增彊 MRI 診斷原髮型肝癌具有較高的診斷效能,但仍需大樣本設計良好的研究進一步證實其臨床運用價值。
목적：대구새산이납증강 MRI 재간경화배경하진단원발형간암적문헌진행회췌분석,평개구새산이납증강 MRI 재간경화배경하진단원발형간암적개치。방법검색수거고포괄 MEDLINE, EMBASE, Cochrane Library databas-es,검색시간위2000년1월도2015년3월。제취상관수거,채용 Stata 12．0급 Meta-Disc 1．4연건진행 Meta 분석。결과최종납입16편삼고문헌,공계2474개병조。 Meta 분석결과시,구새산이납증강 MRI 재간경화배경하진단원발형간암적민감성、특이성、곡선하면적분별위0．921(95% CI：0．887,0．946),0．909(95% CI：0．823,0．955)화0．96(95% CI：0．94,0．97)。결론구새산이납증강 MRI 진단원발형간암구유교고적진단효능,단잉수대양본설계량호적연구진일보증실기림상운용개치。
Objective To perform a systematic review and meta-analysis of the diagnostic performance of gadoxetic acid disodium(Gd-EOB-DTPA)- enhanced magnetic resonance imaging(MRI)as noninvasive modality for evaluating hepatocellular car-cinoma(HCC)in patients with cirrhosis. Methods Databases including MEDLINE , EMBASE, and Cochrane Library databases were searched for relevant original articles published from January 2000 to March 2015. Sensitivities, specificities,and areas under the receiver operating characteristic curve(AUC)were calculated. Potential threshold effect, heterogeneity, and publication bias were investigated. Results Across 16 studies of 2474 lesions were included. The overall per-lesion Gd-EOB-DTPA- enhanced MRI sensitivity was 0. 921(95% CI:0. 887,0. 946), and specificity was 0. 909(95% CI:0. 823,0. 955). The area under the curve of the summary receiver operator characteristic(ROC)was 0. 96(95% CI:0. 94,0. 97). Conclusion MRI with gadoxetic acid disodium is a noninvasive and no radiation exposure imaging modality with high sensitivity and specificity for the detection of HCC in patients with cirrhosis. Nonetheless, large-scale well-designed trials are necessary to assess its clinical value.
