CAJ | 학술논문

目的：：分析冠心病(CHD)患者血清超敏 C 反应蛋白(hs-CRP)和胱抑素 C(Cys-C)水平变化。方法：125例 CHD 患者分为急性心肌梗死组(AMI 组,n=24)、不稳定性心绞痛组(UA 组,n=73)、稳定性心绞痛组(SA组,n=28),同期因胸闷、胸痛症状经冠状动脉造影排除 CHD 的患者作为对照组(n=80)。采用免疫比浊法测定各组血清 hs-CRP 和 Cys-C 浓度,统计分析各组间差异及二者单检和联检对 CHD 的诊断效能。结果：CHD 各组血清hs-CRP 和 Cys-C 水平均高于对照组,差异有统计学意义(P <0.01)。血清 hs-CRP 和 Cys-C 诊断 CHD 的 ROC 曲线下面积分别为0.70(95%CI：0.63-0.77)和0.72(95%CI：0.66-0.79),二者联合检测诊断 CHD 的 ROC 曲线下面积为0.76(95%CI：0.70-0.83)。以4.23mg/L 为 Cut-off 值,血清 hs-CRP 诊断 CHD 的灵敏度为82.40%,特异度为53.70%；以1.37mg/L 为 Cut-off 值,血清 Cys-C 诊断 CHD 的灵敏度为77.70%,特异度为60.20%；二者联合检测的灵敏度和特异度分别为84.30%和65.40%。结论：hs-CRP 和 Cys-C 水平与 CHD 的发生发展有关,二者血清水平联合检测可以提高 CHD 诊断的灵敏度和特异度。
목적：：분석관심병(CHD)환자혈청초민 C 반응단백(hs-CRP)화광억소 C(Cys-C)수평변화。방법：125례 CHD 환자분위급성심기경사조(AMI 조,n=24)、불은정성심교통조(UA 조,n=73)、은정성심교통조(SA조,n=28),동기인흉민、흉통증상경관상동맥조영배제 CHD 적환자작위대조조(n=80)。채용면역비탁법측정각조혈청 hs-CRP 화 Cys-C 농도,통계분석각조간차이급이자단검화련검대 CHD 적진단효능。결과：CHD 각조혈청hs-CRP 화 Cys-C 수평균고우대조조,차이유통계학의의(P <0.01)。혈청 hs-CRP 화 Cys-C 진단 CHD 적 ROC 곡선하면적분별위0.70(95%CI：0.63-0.77)화0.72(95%CI：0.66-0.79),이자연합검측진단 CHD 적 ROC 곡선하면적위0.76(95%CI：0.70-0.83)。이4.23mg/L 위 Cut-off 치,혈청 hs-CRP 진단 CHD 적령민도위82.40%,특이도위53.70%；이1.37mg/L 위 Cut-off 치,혈청 Cys-C 진단 CHD 적령민도위77.70%,특이도위60.20%；이자연합검측적령민도화특이도분별위84.30%화65.40%。결론：hs-CRP 화 Cys-C 수평여 CHD 적발생발전유관,이자혈청수평연합검측가이제고 CHD 진단적령민도화특이도。
Objective:To investigate the diagnostic value of serum high-sensitivity C-reaction protein (hs-CRP)and cystatin C (Cys-C)level in coronary heart disease (CHD)patients.Method:125 patients with CHD were classipied in acute myocardical infarction(AMI group)24cases,unstable angina(UA group)73 cases and stable angina (SA group)28 cases,another 80 subjects without CHD were taken as controls.All patients were detected the fasting blood levels of serum hs-CRP and Cys-C.Results:The levels of serum hs-CRP and Cys-C were statistically signifi-cant difference between CHD groups and control group(P <0.01),also had difference among each CHD groups. ROC analysis showed that the value of serum hs-CRP and Cys-C were 0.70 and 0.72 in diagnosis of CHD.4.23mg/L was set as Cut-off value,the sensitivity serum hs-CRP was 82.40% and specifity was 53.70% in diagnosis of CHD;While 1.37mg/L was set as Cut-off value,the sensitivity of serum Cys-C was 77.70% and specifity was 60. 20%;Combined detection of them,the sensitivity was 84.30% and specifity was 65.40%.Conclusion:The serum levels of hs-CRP and Cys-C were closely related to CHD and the combined detection of them was very important for the diagnosis and assessment of CHD.