CAJ | 학술논문

目的：观察细辛脑佐治儿童喘息性支气管炎(喘支)的临床效果和作用机制。方法选择2011年1月至2014年10月麻城市妇幼保健院儿科确诊的喘支急性期住院患儿70例，随机分为细辛脑佐治组(n=35)和基础治疗组(n=35)；同时，选取体检健康儿童30例为正常对照组。基础治疗组给予基础治疗，细辛脑佐治组给予完全相同的基础治疗，再加用细辛脑注射液雾化吸入。对两个治疗组的疗效、症状与体征消失时间等进行比较分析；测评并比较两组患儿外周血淋巴细胞上清液中 IL-2、IFN-γ、IL-4和 IL-10的含量。结果1)与基础治疗组比较，细辛脑佐治组治愈率明显升高(P <0.05)，喘息、咳嗽、肺部哮鸣音和湿啰音等症状、体征消失时间明显缩短(P <0.01、P <0.05)。与正常对照组比较，治疗前两个治疗组淋巴细胞上清液 IL-2和 IFN-γ水平均明显下降(P <0.01)；治疗后均明显上升(P <0.01、P <0.05)，且细辛脑佐治组比基础治疗组升高更明显(P <0.05)；治疗前两组IL-4和 IL-10水平皆明显升高(P <0.01)，治疗后皆明显下降(P <0.01、P <0.05)，且细辛脑佐治组比基础治疗组下降更明显(P <0.05)。结论细辛脑对儿童喘支有良好的辅助治疗效果，其机制可能与细辛脑重塑淋巴细胞Th1/Th2平衡相关。
목적：관찰세신뇌좌치인동천식성지기관염(천지)적림상효과화작용궤제。방법선택2011년1월지2014년10월마성시부유보건원인과학진적천지급성기주원환인70례，수궤분위세신뇌좌치조(n=35)화기출치료조(n=35)；동시，선취체검건강인동30례위정상대조조。기출치료조급여기출치료，세신뇌좌치조급여완전상동적기출치료，재가용세신뇌주사액무화흡입。대량개치료조적료효、증상여체정소실시간등진행비교분석；측평병비교량조환인외주혈림파세포상청액중 IL-2、IFN-γ、IL-4화 IL-10적함량。결과1)여기출치료조비교，세신뇌좌치조치유솔명현승고(P <0.05)，천식、해수、폐부효명음화습라음등증상、체정소실시간명현축단(P <0.01、P <0.05)。여정상대조조비교，치료전량개치료조림파세포상청액 IL-2화 IFN-γ수평균명현하강(P <0.01)；치료후균명현상승(P <0.01、P <0.05)，차세신뇌좌치조비기출치료조승고경명현(P <0.05)；치료전량조IL-4화 IL-10수평개명현승고(P <0.01)，치료후개명현하강(P <0.01、P <0.05)，차세신뇌좌치조비기출치료조하강경명현(P <0.05)。결론세신뇌대인동천지유량호적보조치료효과，기궤제가능여세신뇌중소림파세포Th1/Th2평형상관。
Objective To study the clinical efficacy and its mechanism of added-on asarone in treating children patients with asthmatic bronchitis.Methods 70 children with asthmatic bronchitis were randomly divided into basic therapy group (n=35)and asarone added-on therapy group (n=35).At the same time,a normal control group was set consisting of 30 healthy children.Basic treatment was used in the basic therapy group and vapour inhalation of asarone injection was added on the basis of basic therapy in the asarone added-on therapy group.Efficacies, disappearance time of signs and symptoms of the two groups were compared and statistically analyzed.The levels of IL-2,IFN-γ,IL-4 and IL-10 in peripheral blood lymphocyte supernatant obtained from patients from the two groups were evaluated and compared.Results Compared with the basic therapy group,the cure rate of the asarone added-on therapy group was significantly increased (P <0.05 );The disappearance time of signs and symptoms such as wheeze,cough,pulmonary wheezing sound and moist rales were notably shortened(P <0.01,P <0.05).Compared with the normal controls,the supernatant levels of IL-2 and IFN-γ of the two therapy groups were significantly decreased (P <0.01 )before treatment and distinctly increased after treatment (P < 0.01、P < 0.05 ),the rise of which was more apparent in the asarone added-on therapy group than the basic therapy group (P < 0.05 ). Meanwhile,the supernatant levels of IL-4 and IL-10 in the two therapy groups were markedly increased (P <0.01) before treatment and visibly decreased after treatment (P <0.01、P <0.05),the decline of which was more obvious in the asarone added-on therapy group than the basic therapy group (P <0.05 ).Conclusion Asarone has a good auxiliary effect in treating asthmatic bronchitis.Its mechanism may involve asarone′s remodeling the balance of lymphocyte Th1/Th2.