CAJ | 학술논문

目的：：观察幼龄自发性高血压大鼠(SHR)发病早期淋巴微循环的自律运动特征。方法：手术暴露3周龄雄性 SHR(SHR 组,n=11)和 Wistar 大鼠(Wistar 组,n=11)肠系膜集合淋巴管,采用活体显微录像设备连续视频录像,使用 Vastrack 自律运动跟踪技术对视频录像进行动态测量分析,比较两组大鼠肠系膜集合淋巴管自律运动收缩频率、相对振幅、收缩时长、舒缩时长、收缩振幅、舒张振幅、收缩速度、舒张速度、收缩/舒张时长比、收缩分数和收缩活力指数的差异。结果：SHR 组大鼠淋巴微循环自律运动的相对振幅、收缩振幅、舒张振幅、收缩时长、舒张时长、收缩速度、舒张速度和收缩分数较 Wistar 组大鼠轻度降低,收缩频率、收缩/舒张时长比和收缩活力指数较 Wistar 组大鼠小幅上升,但差异均无统计学意义(P >0.05)。结论：自发性高血压早期幼鼠集合淋巴管自律运动特征未见显著改变,提示其淋巴微循环尚未发生明显功能紊乱。
목적：：관찰유령자발성고혈압대서(SHR)발병조기림파미순배적자률운동특정。방법：수술폭로3주령웅성 SHR(SHR 조,n=11)화 Wistar 대서(Wistar 조,n=11)장계막집합림파관,채용활체현미록상설비련속시빈록상,사용 Vastrack 자률운동근종기술대시빈록상진행동태측량분석,비교량조대서장계막집합림파관자률운동수축빈솔、상대진폭、수축시장、서축시장、수축진폭、서장진폭、수축속도、서장속도、수축/서장시장비、수축분수화수축활력지수적차이。결과：SHR 조대서림파미순배자률운동적상대진폭、수축진폭、서장진폭、수축시장、서장시장、수축속도、서장속도화수축분수교 Wistar 조대서경도강저,수축빈솔、수축/서장시장비화수축활력지수교 Wistar 조대서소폭상승,단차이균무통계학의의(P >0.05)。결론：자발성고혈압조기유서집합림파관자률운동특정미견현저개변,제시기림파미순배상미발생명현공능문란。
Objective:To characterize the vasomotion pattern of lymphatic microcuculation in juvenile SHR rats at nascent stage of hypertension.Method:Spontaneous contraction cycles of mesenteric collecting lymphatics in 3-week-old male spontaneously hypertensive rats (SHR group,n = 1 1 )and age-matched Wistar controls (Wistar group,n = 1 1 )were recorded with intravital video microscope.Lymphatic vasomotion videos were dynamically tracked and determined by automated Vastrack technique.Contractile parameters included relative amplitude,con-traction frequency,speed,duration and amplitude of vessel wall movement at systolic and diastolic stage,ratio of duration on systole to diastole,contractile fraction and contractile activity index were investigated.Results:Mean systolic speed,systolic and diastolic amplitudes of collecting lymphatics in 3-week-old SHRs exhibited slight but not significant diminutions (P > 0.05 ),while frequency and contractile activity index showed mild augments.Conclu-sion:At the onset of the hypertension progression in juvenile SHR rats,vasomotion pattern of collecting lymphatics exhibited no pronounced alterations,indicate that profound disturbance has not formed in lymphatic microcuculation.