CAJ | 학술논문

目的：观察动脉弹性、氧化低密度脂蛋白（ox－LDL）、白细胞介素－6（IL－6）、基质金属蛋白酶－3（MMP－3）在冠心病特别是冠状动脉（冠脉）轻度狭窄患者中的变化情况，评价其临床意义。方法将132例患者根据冠脉造影结果分为对照组、冠脉轻度狭窄组、冠心病组，用欧姆龙科林动脉硬化检测仪检测反映动脉弹性的肱－踝脉搏波传导速度（baPWV），静脉抽血ELISA方法检测ox－LDL、IL－6、MMP－3。结果3组比较baPWV、ox－LDL、IL－6、MMP－3差异均有统计学意义（ P＜0.05）。与对照组比较，冠脉轻度狭窄组baPWV、IL－6、ox－LDL明显升高（P＜0.05），MMP－3未见明显升高，差异无统计学意义（P＞0.05）。将选入的患者baPWV与ox－LDL、IL－6做直线相关分析，结果呈正相关（r＝0.472、0.523，P＜0.001）。在控制了吸烟、高血压病史、糖尿病史等多种动脉粥样硬化危险因素后，这种相关性仍然存在（ r＝0.435、0.506，P＜0.01）。结论冠脉轻度狭窄患者动脉弹性与炎症和氧化应激、炎症密切相关，提示动脉弹性、氧化应激与炎症参与了早期冠脉粥样硬化的发生与发展，联合这些指标的检测可能可以预测冠脉的轻度狭窄病变。
목적：관찰동맥탄성、양화저밀도지단백（ox－LDL）、백세포개소－6（IL－6）、기질금속단백매－3（MMP－3）재관심병특별시관상동맥（관맥）경도협착환자중적변화정황，평개기림상의의。방법장132례환자근거관맥조영결과분위대조조、관맥경도협착조、관심병조，용구모룡과림동맥경화검측의검측반영동맥탄성적굉－과맥박파전도속도（baPWV），정맥추혈ELISA방법검측ox－LDL、IL－6、MMP－3。결과3조비교baPWV、ox－LDL、IL－6、MMP－3차이균유통계학의의（ P＜0.05）。여대조조비교，관맥경도협착조baPWV、IL－6、ox－LDL명현승고（P＜0.05），MMP－3미견명현승고，차이무통계학의의（P＞0.05）。장선입적환자baPWV여ox－LDL、IL－6주직선상관분석，결과정정상관（r＝0.472、0.523，P＜0.001）。재공제료흡연、고혈압병사、당뇨병사등다충동맥죽양경화위험인소후，저충상관성잉연존재（ r＝0.435、0.506，P＜0.01）。결론관맥경도협착환자동맥탄성여염증화양화응격、염증밀절상관，제시동맥탄성、양화응격여염증삼여료조기관맥죽양경화적발생여발전，연합저사지표적검측가능가이예측관맥적경도협착병변。
Objective To investigate the changes of arterial elasticity , levels of ox-LDL, IL-6 and MMP-3 and their clinical significance in patients with mild stenosis of coronary artery .Methods One hundred and thirty -two patients who underwent coronary angiography were divided into three groups according to the result of CAG :coronary heart disease group, the group with mild stenosis of coronary artery and control group .Brachial -ankle pulse wave velocity (baPWV), which reflected arterial elasticity, was measured by a Colin system.Serum levels of ox -LDL, IL-6 and MMP-3 were measured via ELISA before angiography in all subjects .Results Statistically significant differences were observed among three groups in baPWV and the levels of ox -LDL, IL-6 and MMP-3 (P<0.05).Comparing with the control group, there were significant increases in baPWV and levels of ox -LDL, IL-6 in the group with mild stenosis of coronary artery (P<0.05).Levels of MMP-3 were not significantly different between the two groups (P>0.05).baP-WV was positively correlated with ox -LDL and IL-6 (r=0.472,0.523; P<0.001).The correlation remained after control for risk factors of atherosclerosis such as smoking , hypertension and diabetes (r=0.435, 0.506; P<0.01). Conclusion Changes of arterial elasticity is correlated with inflammation and oxidative stress in patients with mild steno -sis of coronary artery , which indicates their contribution to occurrence and development of early coronary atherosclerosis . Detection of these indicators may predict mild stenosis of coronary arteries .