CAJ | 학술논문

目的：初步探讨体素内不相干运动扩散加权成像(IVIM-DWI)在乳腺良、恶性病变鉴别诊断中的应用。方法测量60例行1.5 T 磁共振扫描的乳腺疾病患者病变的 IVIM 参数：标准扩散系数(Standard ADC)、真实扩散系数(Slow ADC)、灌注相关扩散系数(Fast ADC)及灌注系数 f(Fraction)值。根据病理结果将患者分为良、恶性病变组,并取其自身对侧正常的乳腺组织为对照组,对3组的定量参数进行统计学分析。比较3组的组内Standard ADC、Slow ADC 值的差别,分析其 ROC 曲线。结果对照组、良性病变与恶性病变组的 Standard ADC、Slow ADC 值依次降低,且两两比较差别有统计学意义(P <0.01)；对照组、良性病变与恶性病变组的 Fast ADC、Fraction 值依次升高,进一步两两比较,Fraction 值的差别有统计学意义(P <0.01),Fast ADC 值仅对照组与良性病变组间的差别有统计学意义(P <0.01)。3组组内 Standard ADC 和 Slow ADC 值的差别有统计学意义(P <0.01),Slow ADC 的 ROC 曲线下面积大于 Standard ADC。结论IVIM-DWI 对乳腺良恶性病变的鉴别诊断有意义,可提高诊断的敏感性。
목적：초보탐토체소내불상간운동확산가권성상(IVIM-DWI)재유선량、악성병변감별진단중적응용。방법측량60례행1.5 T 자공진소묘적유선질병환자병변적 IVIM 삼수：표준확산계수(Standard ADC)、진실확산계수(Slow ADC)、관주상관확산계수(Fast ADC)급관주계수 f(Fraction)치。근거병리결과장환자분위량、악성병변조,병취기자신대측정상적유선조직위대조조,대3조적정량삼수진행통계학분석。비교3조적조내Standard ADC、Slow ADC 치적차별,분석기 ROC 곡선。결과대조조、량성병변여악성병변조적 Standard ADC、Slow ADC 치의차강저,차량량비교차별유통계학의의(P <0.01)；대조조、량성병변여악성병변조적 Fast ADC、Fraction 치의차승고,진일보량량비교,Fraction 치적차별유통계학의의(P <0.01),Fast ADC 치부대조조여량성병변조간적차별유통계학의의(P <0.01)。3조조내 Standard ADC 화 Slow ADC 치적차별유통계학의의(P <0.01),Slow ADC 적 ROC 곡선하면적대우 Standard ADC。결론IVIM-DWI 대유선량악성병변적감별진단유의의,가제고진단적민감성。
Objective To investigate the value of parameters derived by IVIM-DWI in differentia-tial diagnosis of benign and malignant breast lesions. Methods Sixty patients underwent MRI at 1.5 T had pathology-proven diagnosis. All lesions were identified using the following parameters:Standard ADC,Slow ADC,Fast ADC and Fraction. All the parameters of malignant,benign and normal glandu-lar tissues were analyzed. The differences between Standard ADC and Slow ADC were analyzed. Results Mean Standard ADC and Slow ADC were lower in malignant tumors than that in benign lesions. Mean Standard ADC and Slow ADC were higher in normal glandular than that in benign lesions. There were significant differences between malignant and benign lesions,malignant lesions and normal glandular tissues,benign lesions and normal glandular tissues in mean Standard ADC and Slow ADC. Mean Fast ADC and Fraction was higher in malignant tumors than that in benign lesions. Mean Fast ADC and Frac-tion was lower in normal glandular tissues than that in benign lesions. There were significant differences between malignant and benign lesions,malignant lesions and normal glandular tissues in mean Fraction. Mean Fast ADC showed no significant differences between malignant and benign lesions,malignant lesions and normal glandular tissues but between benign lesions and normal glandular. There were essential differences between mean Standard ADC and mean Slow ADC in all groups. Area under the ROC of Slow ADC was bigger than that of Standard ADC. Conclusion IVIM-MRI has potential role in estimating the benign and malignant breast lesions. Using IVIM-DWI increases the sensitivity of differentiating malig-nant lesions from benign tissues.