CAJ | 학술논문

目的：探讨自拟醒脑化瘀汤对急性脑梗死患者神经功能及血清炎症因子表达水平的影响。方法将95例急性脑梗死患者随机分为试验组47例和对照组48例,对照组给予常规治疗,试验组在此基础上加用自拟醒脑化瘀汤。结果临床有效率：试验组为95.74%(45/47),对照组为81.25%(39/48),差异有统计学意义(P <0.05)。治疗14 d 后,两组美国国立卫生研究院卒中量表(NIHSS)评分均降低(P <0.01),Barthel 指数量表评分均升高(P <0.01),且组间比较差异均有统计学意义(P <0.01)。两组治疗后血清超敏 C 反应蛋白(hs-CRP)、白介素1β(IL-1β)和肿瘤坏死因子α(TNF-α)水平均下降,且试验组低于对照组,差异均有统计学意义(P <0.01)。结论在常规治疗的基础上加用活血化瘀类中药汤剂可有效提高急性脑梗死的临床疗效,改善患者神经功能和日常生活能力,降低血清炎症因子表达水平,且具有较高的安全性。
목적：탐토자의성뇌화어탕대급성뇌경사환자신경공능급혈청염증인자표체수평적영향。방법장95례급성뇌경사환자수궤분위시험조47례화대조조48례,대조조급여상규치료,시험조재차기출상가용자의성뇌화어탕。결과림상유효솔：시험조위95.74%(45/47),대조조위81.25%(39/48),차이유통계학의의(P <0.05)。치료14 d 후,량조미국국립위생연구원졸중량표(NIHSS)평분균강저(P <0.01),Barthel 지수량표평분균승고(P <0.01),차조간비교차이균유통계학의의(P <0.01)。량조치료후혈청초민 C 반응단백(hs-CRP)、백개소1β(IL-1β)화종류배사인자α(TNF-α)수평균하강,차시험조저우대조조,차이균유통계학의의(P <0.01)。결론재상규치료적기출상가용활혈화어류중약탕제가유효제고급성뇌경사적림상료효,개선환자신경공능화일상생활능력,강저혈청염증인자표체수평,차구유교고적안전성。
Objective To explore the effect of self-made Xingnao Huayu Decoction on neurological function and serum inflammatory cytokines expressions of patients with acute cerebral infarction.Methods A total of 95 patients with acute cerebral infarction were selected and randomly divided into experimental group (n = 47 )and control group (n=48).Patients in control group were given conventional treatment while patients in experimental group were treated with Xingnao Huayu Decoction additionally.Results The clinical effective rate in experimental group was 95.74%,which was higher than 81.25% in control group,and the difference is statistically significant (P <0.05).After 14 days of treatment,the National Institutes of Health Stroke Scale (NIHSS)scores decreased (P <0.01)and Barthel Index Scale scores increased in both groups (P <0.01 ),and the differences between both groups were statistically significant(P <0.01).Serum high sensitivity C-reactive protein (hs-CRP),interleukin-1β(IL-1β)and tumor necrosis factor-α (TNF-α)expressions decreased in both groups after treatment with a better effect in experimental group and the difference was statistically significant (P <0.01).Conclusion On the basis of conventional therapy,extra usage of Xingnao Huayu Decoction can effectively and safely improve the clinical efficacy,neurological function and activities of daily living and decrease serum inflammatory cytokines expressions in patients with acute cerebral infarction.