中华老年多器官疾病杂志
中華老年多器官疾病雜誌
중화노년다기관질병잡지
Chinese Journal of Multiple Organ Diseases in the Elderly
2015年
11期
854-858
,共5页
陈海威%夏云峰%熊丹%翟红霞
陳海威%夏雲峰%熊丹%翟紅霞
진해위%하운봉%웅단%적홍하
慢性肾功能衰竭%对氧磷酶1%心脏结构
慢性腎功能衰竭%對氧燐酶1%心髒結構
만성신공능쇠갈%대양린매1%심장결구
chronic renal failure%paraoxonase 1%cardiac structure
目的:探讨慢性肾功能衰竭(CRF)患者血清对氧磷酶1(PON1)水平与心脏结构改变的相关性。方法连续性收录2013年1月至2015年4月于解放军总医院第一附属医院住院治疗的80例CRF患者作为CRF组,40例无肾脏疾病的体检患者作为对照组。比较分析血清PON1等氧化应激指标的改变,以及和心脏结构的相关性。结果慢性肾脏病(CKD)5期患者左室舒张末期内径(LVDd)、左室质量(LVM)和左室质量指数(LVMI)水平明显高于对照组(P<0.05)。CKD5期患者总抗氧化态(TAS)明显低于对照组(P<0.05),氧化应激指数(OSI)水平明显高于对照组(P<0.05)。CKD患者血清PON1水平与LVM(r=-0.641,P=0.033)和LVMI(r=-0.562,P=0.029)呈负相关。血清PON1水平作为自变量能分别进入LVM(P=0.013)和LVMI (P=0.037)为因变量的线性回归模型方程。结论 CRF患者体内PON1水平明显下降,可以作为一个独立的危险因素对心室结构产生影响。
目的:探討慢性腎功能衰竭(CRF)患者血清對氧燐酶1(PON1)水平與心髒結構改變的相關性。方法連續性收錄2013年1月至2015年4月于解放軍總醫院第一附屬醫院住院治療的80例CRF患者作為CRF組,40例無腎髒疾病的體檢患者作為對照組。比較分析血清PON1等氧化應激指標的改變,以及和心髒結構的相關性。結果慢性腎髒病(CKD)5期患者左室舒張末期內徑(LVDd)、左室質量(LVM)和左室質量指數(LVMI)水平明顯高于對照組(P<0.05)。CKD5期患者總抗氧化態(TAS)明顯低于對照組(P<0.05),氧化應激指數(OSI)水平明顯高于對照組(P<0.05)。CKD患者血清PON1水平與LVM(r=-0.641,P=0.033)和LVMI(r=-0.562,P=0.029)呈負相關。血清PON1水平作為自變量能分彆進入LVM(P=0.013)和LVMI (P=0.037)為因變量的線性迴歸模型方程。結論 CRF患者體內PON1水平明顯下降,可以作為一箇獨立的危險因素對心室結構產生影響。
목적:탐토만성신공능쇠갈(CRF)환자혈청대양린매1(PON1)수평여심장결구개변적상관성。방법련속성수록2013년1월지2015년4월우해방군총의원제일부속의원주원치료적80례CRF환자작위CRF조,40례무신장질병적체검환자작위대조조。비교분석혈청PON1등양화응격지표적개변,이급화심장결구적상관성。결과만성신장병(CKD)5기환자좌실서장말기내경(LVDd)、좌실질량(LVM)화좌실질량지수(LVMI)수평명현고우대조조(P<0.05)。CKD5기환자총항양화태(TAS)명현저우대조조(P<0.05),양화응격지수(OSI)수평명현고우대조조(P<0.05)。CKD환자혈청PON1수평여LVM(r=-0.641,P=0.033)화LVMI(r=-0.562,P=0.029)정부상관。혈청PON1수평작위자변량능분별진입LVM(P=0.013)화LVMI (P=0.037)위인변량적선성회귀모형방정。결론 CRF환자체내PON1수평명현하강,가이작위일개독립적위험인소대심실결구산생영향。
ObjectiveToinvestigate the correlation ofserum level ofparaoxonase 1(PON1) withalterationsof cardiac structure inthe patients with chronic renal failure(CRF).Methods Eighty CRF patientsadmitted in ourhospital from January 2013 to April 2015 were recruited in this study, and 40individuals without any renal diseases whotook physical examination during the same period served ascontrols. The serum PON1 level, total oxidation state(TOS), total anti-oxidation state(TAS) and oxidative stress index were measured and analyzed. Echocardiography was carried out toevaluate the heart structure.ResultsLeft ventricular end diastolic diameter (LVDd), left ventricular mass(LVM) and left ventricular mass index(LVMI) were significantlylarger in CRF patients at stage5chronic kidney disease(CKD) thanincontrols(P<0.05). TASwas significantly lower,while oxidative stress index (OSI) higher in CRF patientsatstage 5CKD thanincontrols(P<0.05). Theserumlevel of PON1 was negatively correlated with LVM(r=-0.641,P=0.033)and LVMI (r=-0.562,P=0.029), and asanindependentvariable, it could enter thelinear regression model withLVM (P=0.013) and LVMI (P=0.037) asdependent variables, respectively.Conclusion Theserumlevel of PON1is significantly decreasedin CRF patients, andcan be regarded asan independent risk factor for cardiac structure.