国际外科学杂志
國際外科學雜誌
국제외과학잡지
International Journal of Surgery
2015年
10期
658-663
,共6页
肝动脉化疗栓塞%微波,消融%肝肿瘤%治疗效果
肝動脈化療栓塞%微波,消融%肝腫瘤%治療效果
간동맥화료전새%미파,소융%간종류%치료효과
Transcatheter arterial chemoembolization%Microwaves,coagulation%Liver neoplasms%Treatment outcome
目的 系统评价肝动脉化疗栓塞(TACE)联合微波消融(PMCT)治疗中晚期肝癌效果.方法 计算机检索国内外文献数据库,包括万方数据库、重庆维普中文科技期刊全文数据库(VIP)、中国期刊全文数据(CNKI)、PubMed、Cochrane Library 、CBM、EMBASE、Medline数据库,查找所有比较TACE联合PMCT与单纯TACE治疗中晚期肝癌效果的随机对照试验,检索时限为2005年1月-2015年5月,涵盖完全缓解(CR)、部分缓解(PR),总有效率、AFP下降水平,1、2、3年生存率.采用Cochrane协作网提供的专用软件RevMan 5.3进行Meta分析.结果 共纳入14篇文献,总计989例患者,联合组470例,单纯组519例Meta分析结果显示TACE联合PMCT治疗中晚期肝癌总有效率较单纯TACE高,AFP下降＞50％,较单纯TACE明显,1年、2年、3年生存率较单纯TACE高,差异均有统计学意义.结论 中晚期肝癌患者选择TACE联合PMCT治疗效果优于单纯TACE治疗.
目的 繫統評價肝動脈化療栓塞(TACE)聯閤微波消融(PMCT)治療中晚期肝癌效果.方法 計算機檢索國內外文獻數據庫,包括萬方數據庫、重慶維普中文科技期刊全文數據庫(VIP)、中國期刊全文數據(CNKI)、PubMed、Cochrane Library 、CBM、EMBASE、Medline數據庫,查找所有比較TACE聯閤PMCT與單純TACE治療中晚期肝癌效果的隨機對照試驗,檢索時限為2005年1月-2015年5月,涵蓋完全緩解(CR)、部分緩解(PR),總有效率、AFP下降水平,1、2、3年生存率.採用Cochrane協作網提供的專用軟件RevMan 5.3進行Meta分析.結果 共納入14篇文獻,總計989例患者,聯閤組470例,單純組519例Meta分析結果顯示TACE聯閤PMCT治療中晚期肝癌總有效率較單純TACE高,AFP下降＞50％,較單純TACE明顯,1年、2年、3年生存率較單純TACE高,差異均有統計學意義.結論 中晚期肝癌患者選擇TACE聯閤PMCT治療效果優于單純TACE治療.
목적 계통평개간동맥화료전새(TACE)연합미파소융(PMCT)치료중만기간암효과.방법 계산궤검색국내외문헌수거고,포괄만방수거고、중경유보중문과기기간전문수거고(VIP)、중국기간전문수거(CNKI)、PubMed、Cochrane Library 、CBM、EMBASE、Medline수거고,사조소유비교TACE연합PMCT여단순TACE치료중만기간암효과적수궤대조시험,검색시한위2005년1월-2015년5월,함개완전완해(CR)、부분완해(PR),총유효솔、AFP하강수평,1、2、3년생존솔.채용Cochrane협작망제공적전용연건RevMan 5.3진행Meta분석.결과 공납입14편문헌,총계989례환자,연합조470례,단순조519례Meta분석결과현시TACE연합PMCT치료중만기간암총유효솔교단순TACE고,AFP하강＞50％,교단순TACE명현,1년、2년、3년생존솔교단순TACE고,차이균유통계학의의.결론 중만기간암환자선택TACE연합PMCT치료효과우우단순TACE치료.
Objective To systematically the efficacy of transcatheter arterial chemoembolization (TACE) conbined with percutaneous microwave coagulation therapy (PMCT) in treatment of advanced liver cancer.Methods A search was performed by retrieving the domestic and foreign literature database,including WanFang Data,VIP,CNKI,PubMed,Cochrane Library,CBM,EMBASE,Medline,between January 2005 and May 2015.These documents were about the analysis of the efficacy of TACE combined with PMCT in treatment of advanced liver cancer,including complete response(CR),partial response(PR),total effective rate,the levels of AFP declining,1,2,and 3 year survival rate and all the trials must be randomized controlled trials.Meta-analyses were conducted using the Cochrane Collaboration's RevMan 5.2 software.Results Fourteen documents were retrieved,including 989 patients,conbined treatment group 470 patients,simple treatment group 519 patients.The results of Mete-analysis shows that the total effective rate of TACE combined with PMCT is higher than TACE alone in treatment of advanced liver cancer.AFP declining ＞ 50％ of TACE combined with PMCT more obvious than TACE alone.1,2,and 3 year survival rate of TACE combincd with PMCT higher than TACE alone.These differences were statistically significant.Conclusion TACE combined with PMCT might be more effective than TACE alone in treatment of advanced liver cancer.
