CAJ | 학술논문

被誉为“NMR中色谱技术”的二维扩散排序NMR谱(DOSY)技术是检测混合物溶液中不同分子组分的一种有效手段。但是当面对自扩散系数差别较小的不同分子时，DOSY技术便无法对上述混合物进行基线分离。在NMR魔角旋转转子或NMR样品管中添加一些色谱填料或高分子等基质（或称为虚拟“色谱固定相”）是一种行之有效的手段。这些虚拟“色谱固定相”与混合物组分发生相互作用并改变其自扩散系数，从而对混合物实现基线分离。该文综述了近年来基质辅助NMR中色谱技术的研究进展。
피예위“NMR중색보기술”적이유확산배서NMR보(DOSY)기술시검측혼합물용액중불동분자조분적일충유효수단。단시당면대자확산계수차별교소적불동분자시，DOSY기술편무법대상술혼합물진행기선분리。재NMR마각선전전자혹NMR양품관중첨가일사색보전료혹고분자등기질（혹칭위허의“색보고정상”）시일충행지유효적수단。저사허의“색보고정상”여혼합물조분발생상호작용병개변기자확산계수，종이대혼합물실현기선분리。해문종술료근년래기질보조NMR중색보기술적연구진전。
Diffusion ordered NMR spectroscopy (DOSY), sometimes also known as chromatographic NMR (CNMR), is a powerful tool for analyzing complex mixture. However, it is often difficult to distinguish components having similar molecular properties using only the diffusion characteristics. A practical way to solve this problem is adding some matrices, such as silica gel or polymers into magic angle spinning rotor or NMR tube, as the virtual stationary phase (VSP), to increase the difference in diffusion rate among different components. Matrix aided CNMR has been shown to have improved discriminating capability when analyzing complex mixtures. In this paper, recent progresses in the field of matrixed CNMR were reviewed.