CAJ | 학술논문

308 nm准分子光是一种单频中波紫外光,为治疗白癜风的首选疗法之一.308 nm准分子光和308 nm准分子激光治疗白癜风的疗效无明显差异.研究表明,308 nm准分子光还可作为银屑病、掌跖脓疱病、斑秃等慢性皮肤病新的治疗选择.目前已有308 nm准分子光治疗无色素痣、蕈样肉芽肿、CD30+淋巴瘤样丘疹病、硬化性苔癣、结节性痒疹、局限性硬皮病、环状肉芽肿及浆细胞唇炎的个案报道,与传统光疗相比,308 nm准分子光累积照射剂量少,发生皮肤癌的风险极低,其不良反应主要为暂时性红斑.308 nm准分子光的治疗机制尚不明确.
308 nm준분자광시일충단빈중파자외광,위치료백전풍적수선요법지일.308 nm준분자광화308 nm준분자격광치료백전풍적료효무명현차이.연구표명,308 nm준분자광환가작위은설병、장척농포병、반독등만성피부병신적치료선택.목전이유308 nm준분자광치료무색소지、심양육아종、CD30+림파류양구진병、경화성태선、결절성양진、국한성경피병、배상육아종급장세포진염적개안보도,여전통광료상비,308 nm준분자광루적조사제량소,발생피부암적풍험겁저,기불량반응주요위잠시성홍반.308 nm준분자광적치료궤제상불명학.
As a kind of monochromatic ultraviolet B,308-nm monochromatic excimer light (MEL) is one of the first choice treatments for vitiligo.There is no significant difference in the therapeutic effect on vitiligo between 308-nm MEL and 308-nm excimer laser.Recent studies have shown that 308-nm MEL can also serve as the treatment of choice for some other chronic skin diseases,such as psoriasis,palmoplantaris pustulosis and alopecia areata.Furthermore,there have been case reports on the use of 308-nm MEL for the treatment of achromic naevus,mycosis fungoides,CD30+ lymphomatoid papulosis,lichen sclerosus,prurigo nodularis,localized scleroderma,granuloma annulare and plasma cell cheilitis.Compared with conventional phototherapy,308-nm MEL has the advantages of less cumulative radiation dose and lower risks of skin cancers.The main adverse reaction to 308-nm MEL is transient erythema.The therapeutic mechanism of 308-nm MEL is still unclear.