CAJ | 학술논문

病理性瘢痕是皮肤受损伤后的异常愈合,以成纤维细胞增殖和胶原蛋白沉积为特征.临床多采用综合疗法治疗瘢痕,取得了一定的疗效.由于某些治疗手段不良反应较大,患者已存在排斥心理.光动力疗法广泛应用于治疗体表的病变,同时其对体内肿瘤的干预疗效也被进行了较多研究.由于光动力疗法低毒性,国内外学者们对其治疗瘢痕的疗效已进行了大量研究.研究表明,光动力疗法能够抑制成纤维细胞的增殖和迁移,诱导凋亡,抑制胞外基质的形成,改善瘢痕外观,对治疗瘢痕有确切疗效.
병이성반흔시피부수손상후적이상유합,이성섬유세포증식화효원단백침적위특정.림상다채용종합요법치료반흔,취득료일정적료효.유우모사치료수단불량반응교대,환자이존재배척심리.광동력요법엄범응용우치료체표적병변,동시기대체내종류적간예료효야피진행료교다연구.유우광동력요법저독성,국내외학자문대기치료반흔적료효이진행료대량연구.연구표명,광동력요법능구억제성섬유세포적증식화천이,유도조망,억제포외기질적형성,개선반흔외관,대치료반흔유학절료효.
Pathological scars are caused by abnormal healing after skin damage,and are characterized by fibroblast proliferation and collagen deposition.At clinics,comprehensive therapy is usually applied for treating scars,and has exerted some therapeutic effects.However,the severe adverse effects of some therapies have caused treatment refusal by patients.Photodynamic therapy has been widely used to treat superficial lesions,and has also been well studied for therapeutic intervention in visceral tumors.Because of the hypotoxicity of photodynamic therapy,its therapeutic effect on scars has been widely studied by domestic and foreign scholars.These researches have shown that photodynamic therapy can inhibit the proliferation and migration of fibroblasts,induce apoptosis,inhibit the formation of extracellular matrix,improve the appearance of scars,and exert definite therapeutic effects on scars.