中医药学报
中醫藥學報
중의약학보
Acta Chinese Medicine and Pharmacology
2015年
5期
31-35
,共5页
张新国%刘英娟%曹心张%张春生%匡彦蓓
張新國%劉英娟%曹心張%張春生%劻彥蓓
장신국%류영연%조심장%장춘생%광언배
中草药%抗氧化活性%DPPH法%FRAP法%总酚含量%黄酮含量
中草藥%抗氧化活性%DPPH法%FRAP法%總酚含量%黃酮含量
중초약%항양화활성%DPPH법%FRAP법%총분함량%황동함량
Chinese medicinal herb%Antioxidant activity%DPPH%FRAP%Phenolic content%Flavonoid content
目的:本研究以常见的22种具有抗肿瘤活性的中药材为对象,对其抗氧化活性进行研究。方法:以DPPH自由基清除率为指标,测定各试样的抗氧化活性;通过FRAP法,Folin-Ciocaheu法以及铝盐显色法,比较其总还原力,总酚含量以及黄酮含量。结果:抗氧化活性大于50%的药材占到了90.09%,其中莪术、虎杖、野生黄芩、白芍、凤尾草、丹参、川断、姜黄等8种药材DPPH的清除作用均超过了90%,显示了较强的抗氧化作用,且野生黄芩的IC50最低(IC50=0.05g/L),抗氧化能力最强,与总还原力的实验结果一致,总酚和黄酮含量也在所有测试品中均为最高,分别为5240μg/L、83210μg/L。结论:除了薏苡仁和茯苓,各试样都有较强的抗氧化活性,表明天然抗氧化剂与其抑癌作用具有一定的相关性,但其相互作用机制需要进一步的探讨研究,本研究为从广泛的天然抗肿瘤资源中寻找抗氧化物质及开发抗氧化型抗肿瘤药物提供了实验依据。
目的:本研究以常見的22種具有抗腫瘤活性的中藥材為對象,對其抗氧化活性進行研究。方法:以DPPH自由基清除率為指標,測定各試樣的抗氧化活性;通過FRAP法,Folin-Ciocaheu法以及鋁鹽顯色法,比較其總還原力,總酚含量以及黃酮含量。結果:抗氧化活性大于50%的藥材佔到瞭90.09%,其中莪術、虎杖、野生黃芩、白芍、鳳尾草、丹參、川斷、薑黃等8種藥材DPPH的清除作用均超過瞭90%,顯示瞭較彊的抗氧化作用,且野生黃芩的IC50最低(IC50=0.05g/L),抗氧化能力最彊,與總還原力的實驗結果一緻,總酚和黃酮含量也在所有測試品中均為最高,分彆為5240μg/L、83210μg/L。結論:除瞭薏苡仁和茯苓,各試樣都有較彊的抗氧化活性,錶明天然抗氧化劑與其抑癌作用具有一定的相關性,但其相互作用機製需要進一步的探討研究,本研究為從廣汎的天然抗腫瘤資源中尋找抗氧化物質及開髮抗氧化型抗腫瘤藥物提供瞭實驗依據。
목적:본연구이상견적22충구유항종류활성적중약재위대상,대기항양화활성진행연구。방법:이DPPH자유기청제솔위지표,측정각시양적항양화활성;통과FRAP법,Folin-Ciocaheu법이급려염현색법,비교기총환원력,총분함량이급황동함량。결과:항양화활성대우50%적약재점도료90.09%,기중아술、호장、야생황금、백작、봉미초、단삼、천단、강황등8충약재DPPH적청제작용균초과료90%,현시료교강적항양화작용,차야생황금적IC50최저(IC50=0.05g/L),항양화능력최강,여총환원력적실험결과일치,총분화황동함량야재소유측시품중균위최고,분별위5240μg/L、83210μg/L。결론:제료의이인화복령,각시양도유교강적항양화활성,표명천연항양화제여기억암작용구유일정적상관성,단기상호작용궤제수요진일보적탐토연구,본연구위종엄범적천연항종류자원중심조항양화물질급개발항양화형항종류약물제공료실험의거。
Objective:In this study ,22 Chinese herbal medicines for anti -cancer were developed for the study of its an-tioxidant activity .Methods:The antioxidant activities of samples were evaluated by DPPH method;phenols , flavonoids contents and total reducing power were estimated by using the Folin -Ciocalteu reagent , aluminum salt colorimetric method and ferric-reducing antioxidant power assay ( FRAP) .Results:The results confirmed that 90 .09%of the medi-cine had characterized the antioxidant activity with more than 50%, which included eight kinds of plant materials such as Rhizoma Curcumae , Rhizoma Polygoni Cuspidati , Wild Skullcaps , Radix Paeoniae Alba , Fern , Salviamiltiorrhiza , Radix Dipsaci Asperoidis , Curcuma longa demonstrated better antioxidant activity ( activity >90%) .Wild Skullcaps demonstrated the best antioxidant activity with the lowest IC 50 value of 0.05g/L, the highest phenolic and flavonoid con-tents of 5240μg/L and 83210μg/L.Conclusion:Each sample for anti -cancer has a strong antioxidant activity except for the Coix seed and Poria , which confirms natural antioxidant and antitumor effect has a certain correlation , but its mechanism needs further research .In this study , it is possible to find antioxidants and antioxidant -based anticancer drugs develop from broad anti -tumor natural resources providing an experimental basis .