CAJ | 학술논문

目的探讨毛囊单位或单株毛囊移植治疗毛发部位白癜风和皮肤镜观察临床疗效的意义.方法以同期接受外用药物治疗的患者作对照,通过皮肤镜检查客观判断、比较毛发部位白癜风采用毛囊单位或单株毛囊移植与对照组的疗效.结果毛囊单位或单株毛囊移植移植治疗毛发部位白癜风的疗效明显优于外用药物治疗组.46处接受移植治疗的皮损中,有12处移植毛囊周围的色素完全恢复,白发消退,显效率54.3％.皮肤镜下最早在术后4周时就可看到毛囊周围色素恢复,并逐渐扩展、融合,色素恢复平均时间9.8周,明显早于肉眼观察到皮肤表面色素恢复时间(平均14.5周).移植后白斑处皮肤微循环得到明显改善,肤质变软、纹理清晰,但与毛囊周围色素岛出现无相关性.患者术后未出现切口明显的瘢痕形成、感染等并发症.结论毛囊单位或单株毛囊移植治疗毛发部位白癜风疗效确切,同时使白斑和白发复色,手术安全,操作简单.
목적 탐토모낭단위혹단주모낭이식치료모발부위백전풍화피부경관찰림상료효적의의.방법 이동기접수외용약물치료적환자작대조,통과피부경검사객관판단、비교모발부위백전풍채용모낭단위혹단주모낭이식여대조조적료효.결과 모낭단위혹단주모낭이식이식치료모발부위백전풍적료효명현우우외용약물치료조.46처접수이식치료적피손중,유12처이식모낭주위적색소완전회복,백발소퇴,현효솔54.3％.피부경하최조재술후4주시취가간도모낭주위색소회복,병축점확전、융합,색소회복평균시간9.8주,명현조우육안관찰도피부표면색소회복시간(평균14.5주).이식후백반처피부미순배득도명현개선,부질변연、문리청석,단여모낭주위색소도출현무상관성.환자술후미출현절구명현적반흔형성、감염등병발증.결론 모낭단위혹단주모낭이식치료모발부위백전풍료효학절,동시사백반화백발복색,수술안전,조작간단.
Objective To evaluate the efficacy of single-hair follicular unit transplantation in the treatment of vitiligo in hair-bearing areas,and to estimate the performance of dermoscopy in efficacy evaluation.Methods Eighty-nine patients with vitiligo in hair-bearing areas were divided into two groups:a treatment group (38 patients with 46 vitiligo lesions) receiving single-hair follicular unit transplantation,a control group (51 patients with 67 vitiligo lesions) treated with topical drugs.Follow up visits were scheduled every 4 weeks for 24 weeks.The growth of epidermal melanocytes and degree of repigmentation were evaluated by both dermoscopy and naked eyes at every visit.Results A better outcome was achieved in the treatment group compared with the control group.Of the 46 vitiligo lesions receiving transplantation,12 achieved complete repigmentation of white hairs and skin around transplanted hair follicles,with a marked response rate of 54.3％.Perifollicular repigmentation was seen by dermoscopy as early as 4 weeks after the transplantation,and gradually expanded and coalesced thereafter.The average time required for the appearance of repigmentation was 9.8 weeks by dermoscopy,markedly shorter than that by naked eyes (14.5 weeks).After transplantation,microcirculation in vitiligo lesions was improved obviously,skin was softened,and skin texture became clear,but no correlation was observed with the appearance of perifollicular pigmentation islands.No complications such as scarring or infection occurred at incision sites after the operation.Conclusion Single-hair follicular unit transplantation is safe,simple to operate,and effective for the treatment of vitiligo in hair-bearing areas.