CAJ | 학술논문

背景：力学性能指标是评价药物治疗骨质疏松动物模型效果的重要方法，以压缩力学性能指标评价多种药物治疗老龄雌性骨质疏松模型动物的效果评价鲜有报道。目的：对大鼠股骨进行压缩力学性能实验，确定不同药物治疗骨质疏松的效果。方法：Wistar雌性大鼠36只随机分为6组：正常组对照组、模型组，丹杞颗粒组，阿法D3组，结合型雌激素组，依普拉芬组，每组6只。除正常组对照组外以去卵巢法复制老龄骨质疏松动物模型，分别以丹杞颗粒、依普拉芬、结合型雌激素(倍美力片)、阿法D3进行治疗，饲养15周后以腹主动脉放血法处死大鼠，取大鼠左、右侧股骨在电子万能实验机上以5 mm/min实验速度进行压缩实验。结果与结论：骨质疏松模型组大鼠股骨最大载荷、最大应力、最大位移、最大应变、弹性模量显著低于正常对照组、丹杞颗粒、依普拉芬、结合型雌激素组(P <0.05)；阿法D3组各项力学性能指标与模型组差异无显著性意义(P >0.05)；丹杞颗粒治疗组上述指标与正常对照组大鼠差异无显著性意义(P >0.05)。结果说明，模型组大鼠由于骨质疏松导致股骨压缩力学特性发生改变。依普拉芬、结合型雌激素组均能提高大鼠股骨压缩力学特性，丹杞颗粒效果最好。
배경：역학성능지표시평개약물치료골질소송동물모형효과적중요방법，이압축역학성능지표평개다충약물치료노령자성골질소송모형동물적효과평개선유보도。목적：대대서고골진행압축역학성능실험，학정불동약물치료골질소송적효과。방법：Wistar자성대서36지수궤분위6조：정상조대조조、모형조，단기과립조，아법D3조，결합형자격소조，의보랍분조，매조6지。제정상조대조조외이거란소법복제노령골질소송동물모형，분별이단기과립、의보랍분、결합형자격소(배미력편)、아법D3진행치료，사양15주후이복주동맥방혈법처사대서，취대서좌、우측고골재전자만능실험궤상이5 mm/min실험속도진행압축실험。결과여결론：골질소송모형조대서고골최대재하、최대응력、최대위이、최대응변、탄성모량현저저우정상대조조、단기과립、의보랍분、결합형자격소조(P <0.05)；아법D3조각항역학성능지표여모형조차이무현저성의의(P >0.05)；단기과립치료조상술지표여정상대조조대서차이무현저성의의(P >0.05)。결과설명，모형조대서유우골질소송도치고골압축역학특성발생개변。의보랍분、결합형자격소조균능제고대서고골압축역학특성，단기과립효과최호。
BACKGROUND:The mechanical index is an important method for the evaluation of the therapeutic efficiency of drug treatment for osteoporosis animal models. OBJECTIVE: To explore the effects of various drug treatments on osteoporosis through a mechanical performance test about the femoral compression of rats. METHODS: Thirty-six Wistar female rats were randomized into six groups: normal control group, model group, Dan Qiparticles group, alpha-D3 group, premarin group, ipriflavone group, with six rats in each group. Osteoporosis models were made in al groups except for the normal control group, and after modeling, the rats in different groups were treated withDan Qi particles, alpha-D3 group, premarin and ipriflavone, respectively. After 15 weeks, the rats were kiled by abdominal aortic bloodletting to take out the left and right femurs that were placed on a universal testing machine to perform a compressive test at a speed of 5 mm/min. RESULTS AND CONCLUSION:The maximum load, maximum stress, maximum displacement, maximum strain, and elastic modulus were significantly lower in the model group than the other four groups (P < 0.05). There was no difference in different mechanical parameters between alpha-D3 group and model group as wel as between Dan Qi particles group and normal control group (P> 0.05). These findings indicate that osteoporosis leads to the variation of compression mechanical properties of the femur. There are good compression mechanical properties of the femur after treatment with premarin and ipriflavone, andDan Qi particles has the best effect.